Antibiotic susceptibility pattern of genital tract bacteria in pregnant women with preterm premature rupture of membranes in a resource‐limited setting

作者: George U Eleje , Joseph I Adinma , Samuel Ghasi , Joseph I Ikechebelu , Anthony O Igwegbe

DOI: 10.1016/J.IJGO.2014.04.016

关键词: Premature rupture of membranesMetronidazoleCefuroximeMedicinePregnancyCefiximeSurgeryAntibiotic sensitivityErythromycinInternal medicineAntibiotics

摘要: Abstract Objective To identify microbes prevalent in the genital tract of pregnant women with preterm premature rupture membranes (PPROM) and to assess susceptibility microbial isolates a range antibiotics determine appropriate for treating cases PPROM resource-limited settings. Methods A prospective cross-sectional study was undertaken involving (n = 105) without confirmed diagnosis admitted Nnamdi Azikiwe University Teaching Hospital, southeast Nigeria, between January 1, 2011, April 30, 2013. Endocervical swabs were collected from all participants examined microbiologically. Antibiotic sensitivity testing performed using Kirby–Bauer disk diffusion. Results Streptococcus spp., Staphylococcus aureus , Escherichia coli significantly more among than those ( P Conclusion For first 48 hours, should receive an intravenous dose combining ampicillin-sulbactam, cefixime, cefuroxime, or erythromycin metronidazole followed by oral administration chosen antibiotic combination complete 7-day course.

参考文章(22)
Sara Kenyon, Michel Boulvain, James P Neilson, Antibiotics for preterm premature rupture of membranes. Cochrane Database of Systematic Reviews. ,(2001) , 10.1002/14651858.CD001058
Nahidi F, Majdfar Z, Hosseini Ma, Comparison of fern and evaporation tests for detection of ruptured fetal membranes. Eastern Mediterranean Health Journal. ,vol. 13, pp. 197- 200 ,(2007)
P. Steer, C. Flint, Preterm labour and premature rupture of membranes BMJ. ,vol. 318, pp. 1059- 1062 ,(1999) , 10.1136/BMJ.318.7190.1059
Errol R Norwitz, Julian N Robinson, Aaron B Caughey, Contemporary Diagnosis and Management of Preterm Premature Rupture of Membranes Reviews in Obstetrics and Gynecology. ,vol. 1, pp. 11- 22 ,(2008)
AE Oyo-Ita, IS Etuk, SJ Etuk, Factors Influencing the Incidence of Pre-term Birth in Calabar, Nigeria. Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria. ,vol. 20, pp. 63- 68 ,(2005) , 10.4314/NJPS.V20I1.32656
Larry M Cousins, Dorothy P Smok, Stuart M Lovett, Deborah M Poeltler, AmniSure Placental Alpha Microglobulin-1 Rapid Immunoassay versus Standard Diagnostic Methods for Detection of Rupture of Membranes American Journal of Perinatology. ,vol. 22, pp. 317- 320 ,(2005) , 10.1055/S-2005-870896
D LEWIS, M FONTENOT, G BROOKS, R WISE, M PERKINS, A HEYMANN, Latency period after preterm premature rupture of membranes: A comparison of ampicillin with and without sulbactam Obstetrics & Gynecology. ,vol. 86, pp. 392- 395 ,(1995) , 10.1016/0029-7844(95)00181-P
C A Hart, S Kariuki, Antimicrobial resistance in developing countries. BMJ. ,vol. 317, pp. 647- 650 ,(1998) , 10.1136/BMJ.317.7159.647
M Pearlman, Prevention of early-onset group B streptococcal disease in newborns Obstetrics & Gynecology. ,vol. 102, pp. 414- 415 ,(2003) , 10.1016/S0029-7844(03)00583-0