Speech acquisition predicts regions of enhanced cortical response to auditory stimulation in autism spectrum individuals

摘要: Abstract A continuum of phenotypes makes up the autism spectrum (AS). In particular, individuals show large differences in language acquisition, ranging from precocious speech to severe onset delay. However, neurological origin this heterogeneity remains unknown. Here, we sought determine whether AS differing acquisition different cortical responses auditory stimulation and morphometric brain differences. Whole-brain activity following exposure non-social sounds was investigated. Individuals were classified according presence or absence of Speech Onset Delay (AS-SOD AS-NoSOD, respectively) compared with IQ-matched typically developing (TYP). AS-NoSOD participants displayed greater task-related than TYP inferior frontal gyrus peri-auditory middle superior temporal gyri, which are associated processing. Conversely, AS-SOD group only showed enhanced vicinity cortex. We detected no structure between groups. This is first study demonstrate existence functional divided their pattern development. These findings support Trigger-threshold-target model indicate that occurrence delay depends on location reallocation, favors perception AS-NoSOD.