SEIZURES | Seizure Termination and the Postseizure Refractory Period

作者: R.F. Berman

DOI: 10.1016/B978-012373961-2.00270-8

关键词: IctalNeuropeptide Y receptorRefractory periodSomatostatinAnticonvulsantHippocampusEpilepsyPsychologyNeuroscienceEndocannabinoid system

摘要: Why seizures stop is an important but largely unanswered question in epilepsy research. The fact that most are self-limiting suggests the operation of some cellular mechanism or mechanisms to terminate ictal activity. purpose this review summarize what known about why seizures, once started, stop. roles potassium homeostasis, GABA, adenosine, neuropeptide Y, somatostatin, and endocannabinoids process considered. Understanding contribute termination ongoing seizure activity important, because such information could not only provide new insights into (and patterning over time), also identify therapeutic targets for control.

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