Chemotherapy of human colon cancer xenografts in athymic nude mice.

摘要: The lack of effective chemotherapy in advanced colon cancer and difficulties evaluating response clinical trials indicate a need for experimental models to screen new agents activity against this specific type cancer. Xenografts human nude mice reproduce many features the original tumor specimen could be expected predict drug with more specificity than previously used screens. NIH-Swiss bearing subcutaneous (s.c.) trocar implants tissue were these studies. Three serially transplantable lines (designated “HT”, “CA”, “BE”), which range their degree differentiation from well-differentiated adenocarcinoma undifferentiated carcinoma, testing. Treatment was delayed until tumors had reached 60-600 mg mass correspond patients. Drugs being developed trial by NCI selected testing xenografts based on promising murine difference mechanism action. Two antimetabolites, PALA Baker's antifol, mitotic spindle poison, maytansine, DNA intercalating agent, AMSA, produced no significant regression any three xenograft lines. From group nitrosoureas, methylCCNU chlorozotocin tested. MethylCCNU caused line HT, transient CA complete regressions BE. Chlorozotocin also BE but effect other results studies reflect situation where few objective responses are achieved presently available chemotherapy. We would conclude that information about may gained panel xenografts. Careful followup parallel systems should establish correlation between individual system.