Heterogeneity of high-density lipoproteins and apolipoprotein A-I as related to quantification of apolipoprotein A-I.
作者： Steven T. Kunitake , Patricia O'Connor , Josefina Naya-Vigne
DOI: 10.1016/S0076-6879(96)63018-3
关键词: Endocrinology 、 High density 、 Distribution (pharmacology) 、 Apolipoprotein B 、 Epitope 、 Biochemistry 、 Cholesterol 、 Internal medicine 、 Apolipoprotein C2 、 Plasma levels 、 Immunoassay 、 Chemistry
摘要: Publisher Summary Apolipoprotein (apo) A-I is the major protein constituent of human plasma high-density lipoproteins (HDL). It present on bulk HDL particles, isolated from fasting normolipidemic individuals. Accurate measurement apoA-I central to study HDL. Plasma levels correlate well with cholesterol and it has been suggested that may actually be a more accurate predictor cardiovascular risk than cholesterol. In addition, complexes are heterogeneous, respect constituents and, therefore, an determination will aid in elucidation apolipoprotein stoichiometry various distribution among them. Direct quantitation apoA-I, by immunoassay, complicated, variability epitopes apoA-I. This arise either structural differences itself or conformational differences, owing association distinct species.
sci-hub.se 参考文章(46)
G Gianfranceschi, A Menotti, C R Sirtori, A Cerrone, V Gualandri, G Franceschini, G B Orsini, AIMilano apoprotein identification of the complete kindred and evidence of a dominant genetic transmission. American Journal of Human Genetics. ,vol. 37, pp. 1083- 1097 ,(1985)
M. Ayrault-Jarrier, E. Bekaert, E. Petit, D. Pastier, J. Polonovski, B. Pau, F. Paolucci, E. Hervaud, M. Laprade, Heterogeneity in the conformation of apo A-I on the surface of HDL particles. Advances in Experimental Medicine and Biology. ,vol. 243, pp. 149- 155 ,(1988) , 10.1007/978-1-4613-0733-4_18
William R. Dito, Robert M. Nakamura, E. S. Tucker, Immunoassays in the clinical laboratory A.R. Liss. ,(1979)
Fondazione Giovanni Lorenzini, Claude Lenfant, Biotechnology of dyslipoproteinemias : applications in diagnosis and control Raven Press. ,(1990)
L K Curtiss, T S Edgington, Immunochemical heterogeneity of human plasma high density lipoproteins. Identification with apolipoprotein A-I- and A-II-specific monoclonal antibodies. Journal of Biological Chemistry. ,vol. 260, pp. 2982- 2993 ,(1985) , 10.1016/S0021-9258(18)89462-5
Antonio Gotto, M. F. Rohde, S. Krishnan, G. Ghiselli, S. Tanenbaum, Origin of apolipoprotein A-I polymorphism in plasma Journal of Biological Chemistry. ,vol. 260, pp. 15662- 15668 ,(1985) , 10.1016/S0021-9258(17)36309-3
Z H Beg, J A Stonik, J M Hoeg, S J Demosky, T Fairwell, H B Brewer, Human apolipoprotein A-I. Post-translational modification by covalent phosphorylation. Journal of Biological Chemistry. ,vol. 264, pp. 6913- 6921 ,(1989) , 10.1016/S0021-9258(18)83518-9
O L Francone, A Gurakar, C Fielding, Distribution and functions of lecithin:cholesterol acyltransferase and cholesteryl ester transfer protein in plasma lipoproteins. Evidence for a functional unit containing these activities together with apolipoproteins A-I and D that catalyzes the esterification and transfer of cell-derived cholesterol. Journal of Biological Chemistry. ,vol. 264, pp. 7066- 7072 ,(1989) , 10.1016/S0021-9258(18)83541-4
R Ronan, J M Hoeg, T Fairwell, H B Brewer, M S Meng, Human apolipoprotein A-I. Post-translational modification by fatty acid acylation. Journal of Biological Chemistry. ,vol. 261, pp. 3911- 3914 ,(1986) , 10.1016/S0021-9258(17)35598-9
L K Curtiss, R S Smith, Localization of two epitopes of apolipoprotein A-I that are exposed on human high density lipoproteins using monoclonal antibodies and synthetic peptides Journal of Biological Chemistry. ,vol. 263, pp. 13779- 13785 ,(1988) , 10.1016/S0021-9258(18)68310-3