作者: B.L. Wong , S.H. Chris Kim , J.M. Antonacci , C. Wayne McIlwraith , R.L. Sah
DOI: 10.1016/J.JOCA.2009.11.008
关键词: Cartilage 、 Internal medicine 、 Hyaluronic acid 、 Endocrinology 、 Shear stress 、 Weight-bearing 、 Shear strength 、 Anatomy 、 Lubrication 、 Chemistry 、 Video microscopy 、 Synovial fluid
摘要: Summary Objective To determine the effects of acute injury and tribosupplementation by hyaluronan (HA) on synovial fluid (SF) modulation cartilage shear during tibio-femoral articulation. Methods Human osteochondral blocks from lateral femoral condyle (LFC) tibial plateau (LTP) were apposed, compressed 13%, subjected to sliding under video microscopy. Tests conducted with equine SF normal joints (NL-SF), acutely injured (AI-SF), AI-SF which HA was added (AI-SF+HA). Local overall strain ( E xz ) displacement (Δ x at reached 50% peak values 1/2 determined. Results During articulation, LFC LTP increased Δ peaked when surfaces slid, being maintained sliding. With as lubricant, surface ∼40% ∼20% higher, respectively, than NL-SF AI-SF+HA lubricant. Also, markedly higher lubricant both near (∼80%) (50–200%). Following supplementation AI-SF, reduced alone 30–50% 20–30% overall. Magnitudes (∼50 80%) in for all lubricants. Conclusion Acute impairs function, elevating articulation; such elevated may contribute post-injury associated degeneration. Since partially restores function indicated , tribosupplements be beneficial modulating homeostasis.