Size-Controlled Biocompatible Silver Nanoplates for Contrast-Enhanced Intravital Photoacoustic Mapping of Tumor Vasculature.

摘要: Triangular Ag nanoplates with a thickness of 5 nm and tunable edge lengths were fabricated using seed-mediated protocol, featuring enhanced near-infrared absorption as the length increased. The photoacoustic (PA) efficiency these assessed. Nanoplates an 100 (r1) performed best among others in vitro assessment. In following vivo test, r1 also found to boost PA signal tumor vessels, while detailed imaging vasculature was obtained. safety assessment demonstrated that no apparent acute toxicity observed heart, liver, spleen, lung kidneys mice single intravenous dose nanoplates. Therefore, selected size have great potential new alternative contrast agent for quantitative imaging-based evaluation angiogenic heterogeneity microenvironment. More importantly, controllable synthesis nanoparticles would be ideal route optimize biomedical application.