HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
作者： Gregg L. Semenza
DOI: 10.1172/JCI67230
关键词: Hypoxia (medical) 、 Cancer cell 、 Oncogene 、 Internal medicine 、 PI3K/AKT/mTOR pathway 、 Oxidative phosphorylation 、 Protein kinase B 、 Glutamine 、 Glycolysis 、 Endocrinology 、 Cancer research 、 Biology
摘要: … that include a switch from oxidative phosphorylation to glycolysis, increased glycogen … by HIF-1, which functions as a master regulator to balance oxygen supply and demand. HIF-1 is …
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