Pathophysiologic Implications of Membrane Phospholipid Asymmetry in Blood Cells

作者: Robert F.A. Zwaal , Alan J. Schroit

DOI: 10.1182/BLOOD.V89.4.1121

关键词: BiochemistryBiophysicsSphingomyelinPhospholipidPhosphatidylcholinePhospholipid transfer proteinMembraneBavituximabChemistryPhospholipid scramblaseRed blood cell

摘要: MANY STUDIES HAVE led to the concept that membrane phospholipid asymmetry is ubiquitous. In general terms, outer leaflet of eukaryotic plasma membranes formed predominantly with cholinephospholipids (sphingomyelin and phosphatidylcholine [PC]), whereas majority

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