RNA Targeting Using Peptide Nucleic Acid
作者： Peter E. Nielsen
DOI: 10.1385/1-59259-823-4:343
关键词: Biochemistry 、 Nucleic acid 、 Nucleic acid methods 、 Sense (molecular biology) 、 RNA 、 Chemistry 、 Peptide nucleic acid 、 Drug discovery 、 Xeno nucleic acid 、 Alternative splicing
摘要: The efforts towards peptide nucleic acid (PNA) drug discovery using cellular RNAs as molecular targets is briefly reviewed, with special emphasis on recent developments. Special attention given to delivery in vivo bioavailability and the possibilities of PNA oligomers (re)direct alternative splicing pre-messenger (m)RNA.
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