Preparation and evaluation of minoxidil foamable emu oil emulsion.
作者： Shatalebi , Y Rafiei
DOI:
关键词: Hair growth 、 Lactic acid 、 Minoxidil 、 Emulsion 、 Chemistry 、 Permeation 、 Potency 、 Organic chemistry 、 Emu oil 、 Ethanol 、 Chromatography
摘要: The aim of this work was to develop and evaluate a minoxidil foamable emu oil emulsion with the purpose improving permeation into skin, increasing hair growth, reducing skin irritation, consumer compliance. Minoxidil dissolved in solvent system comprising ethanol: glycerin: lactic acid: water (10:20:5:65). prepared by mixing phase solution using different amount various emulsifiers. Seventeen formulations were most stable selected evaluated for pharmaceutical parameters such as homogeneity, pH, stability centrifugal stress, freeze-thaw foamability. adopted formulation showed good characteristics. In vitro release rate Franz diffusion cell phosphate buffer pH 7.4 ethanol receiver medium at sink condition. found obey Higuchi kinetic model. Experimental animal study performed growth potential formulation. Different cyclic phases follicles, like anagen, telogen phases, determined one month period. Histological after treatment exhibited greater number follicles anagenic (96%) which higher compared marketed 5% (Pakdaru® 70%) control group (42%). From it concluded that significant potency promoting comparison Pakdaru®.
参考文章(23)
Michael F. Holick, Use of emu oil for stimulating skin and hair growth ,(1995)
Vaishali Rathi, Sengodan Tamizharasi, Jagdish Chandra Rathi, Development and Evaluation of Polyherbal Formulations for Hair Growth Potential Pharmacognosy Research. ,vol. 1, pp. 234- ,(2009)
Herbert A. Lieberman, Leon Lachman, Joseph L. Kanig, The Theory and Practice of Industrial Pharmacy ,(1970)
A. Arzhavitina, H. Steckel, Foams for pharmaceutical and cosmetic application. International Journal of Pharmaceutics. ,vol. 394, pp. 1- 17 ,(2010) , 10.1016/J.IJPHARM.2010.04.028
T. Fischer, Alopezien – Diagnostisches und therapeutisches Management Aktuelle Dermatologie. ,vol. 34, pp. 209- 225 ,(2008) , 10.1055/S-2007-995795
Elise A. Olsen, David Whiting, Wilma Bergfeld, Jeffrey Miller, Maria Hordinsky, Rita Wanser, Paul Zhang, Bruce Kohut, A multicenter, randomized, placebo-controlled, double-blind clinical trial of a novel formulation of 5% minoxidil topical foam versus placebo in the treatment of androgenetic alopecia in men Journal of The American Academy of Dermatology. ,vol. 57, pp. 767- 774 ,(2007) , 10.1016/J.JAAD.2007.04.012
N Adhirajan, T Ravi Kumar, N Shanmugasundaram, Mary Babu, In vivo and in vitro evaluation of hair growth potential of Hibiscus rosa-sinensis Linn. Journal of Ethnopharmacology. ,vol. 88, pp. 235- 239 ,(2003) , 10.1016/S0378-8741(03)00231-9
Engin Senel, Tugrul Purnak, Ceren Sahin, Liquid formulation of minoxidil versus its foam formulation. Indian Journal of Dermatology. ,vol. 56, pp. 462- 462 ,(2011) , 10.4103/0019-5154.84714
Dov Tamarkin, Doron Friedman, Avner Shemer, Emollient foam in topical drug delivery Expert Opinion on Drug Delivery. ,vol. 3, pp. 799- 807 ,(2006) , 10.1517/17425247.3.6.799
Ji Hyun Han, Oh Sang Kwon, Jin Ho Chung, Kwang Hyun Cho, Hee Chul Eun, Kyu Han Kim, Effect of minoxidil on proliferation and apoptosis in dermal papilla cells of human hair follicle. Journal of Dermatological Science. ,vol. 34, pp. 91- 98 ,(2004) , 10.1016/J.JDERMSCI.2004.01.002