Diazotrifluoropropionamido-containing prenylcysteines: syntheses and applications for studying isoprenoid-protein interactions.
作者： Tamara A. Kale , Mark D. Distefano
DOI: 10.1021/OL026752A
关键词: Protein–protein interaction 、 Isoprenoid binding 、 Chemistry 、 Biochemistry 、 Photophore 、 Prenylation 、 Terpenoid 、 A protein
摘要: Photoaffinity-labeled prenylcysteines (1 and 2) incorporating a diazotrifluoropropionamide-based photophore have been prepared. Photolyses of 2 in the presence RhoGDI, protein that interacts with prenylated proteins, prenylcysteine-containing competitors demonstrate effectiveness this photoaffinity-labeled analogue as tool for studying isoprenoid binding sites.
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