Factors contributing to pressure overload-induced immediate early gene expression in adult rat hearts in vivo
作者： Kazuhide Ogino , Bolin Cai , Anguo Gu , Takushi Kohmoto , Noriyoshi Yamamoto
DOI: 10.1152/AJPHEART.1999.277.1.H380
关键词: Hexamethonium 、 Phentolamine 、 Angiotensin II 、 Propranolol 、 Internal medicine 、 Stimulation 、 Atropine 、 Pressure overload 、 Biology 、 Endocrinology 、 Angiotensin II receptor type 1
摘要: We determined the contributions of angiotensin II type 1 receptor (AT1) stimulation, adrenergic and autonomic activation to pressure overload-induced c- fos expression in adult rat heart vivo. was increased pressure-overloaded hearts created by aortic banding compared with sham-operated rats (458 ± 100% vs. sham, P < 0.05). GR-138950, a selective AT1 antagonist, did not blunt this (banding + GR-138950: 458 500 125%, significant). Atropine hexamethonium partially decreased atropine/hexamethonium: 700 67% 400 67%, Phentolamine had no significant effect on expression; however, propranolol inhibited propranolol: 492 108% 154 15%, The inhibition independent decreases rate. Thus factors contributing vivo are different from those neonatal myocytes vitro undergoing stretch.
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