Notch-mediated conversion of activated T cells into stem cell memory-like T cells for adoptive immunotherapy
作者： Taisuke Kondo , Rimpei Morita , Yuumi Okuzono , Hiroko Nakatsukasa , Takashi Sekiya
DOI: 10.1038/NCOMMS15338
关键词: CD40 、 Cytotoxic T cell 、 IL-2 receptor 、 Antigen-presenting cell 、 Interleukin 12 、 Natural killer T cell 、 Cell biology 、 Interleukin 3 、 Interleukin 21 、 Biology
摘要: Adoptive T-cell immunotherapy is a promising approach to cancer therapy. Stem cell memory T (TSCM) cells have been proposed as class of long-lived and highly proliferative cells. CD8+ TSCM can be generated in vitro from naive via Wnt signalling; however, methods do not yet exist for inducing activated or Here, we show strategy generating TSCM-like (iTSCM cells) CD4+ mice humans by coculturing with stromal that express Notch ligand. iTSCM lose PD-1 CTLA-4 expression, produce large number tumour-specific effector after restimulation. This method could therefore used generate antigen-specific adoptive immunotherapy.
nature.com
elsevier.com
harvard.edu
sci-hub.se 参考文章(39)
Sheng Zhou, John D. Schuetz, Kevin D. Bunting, Anne-Marie Colapietro, Janardhan Sampath, John J. Morris, Irina Lagutina, Gerard C. Grosveld, Mitsujiro Osawa, Hiromitsu Nakauchi, Brian P. Sorrentino, The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype Nature Medicine. ,vol. 7, pp. 1028- 1034 ,(2001) , 10.1038/NM0901-1028
Y Jiang, Y Li, B Zhu, T-cell exhaustion in the tumor microenvironment Cell Death and Disease. ,vol. 6, ,(2015) , 10.1038/CDDIS.2015.162
Elizabeth Buchbinder, F. Stephen Hodi, Cytotoxic T lymphocyte antigen-4 and immune checkpoint blockade Journal of Clinical Investigation. ,vol. 125, pp. 3377- 3383 ,(2015) , 10.1172/JCI80012
Lieping Chen, Xue Han, Anti–PD-1/PD-L1 therapy of human cancer: past, present, and future Journal of Clinical Investigation. ,vol. 125, pp. 3384- 3391 ,(2015) , 10.1172/JCI80011
Kristin A. Hogquist, Stephen C. Jameson, William R. Heath, Jane L. Howard, Michael J. Bevan, Francis R. Carbone, T cell receptor antagonist peptides induce positive selection Cell. ,vol. 76, pp. 17- 27 ,(1994) , 10.1016/0092-8674(94)90169-4
Holden T. Maecker, J. Philip McCoy, Robert Nussenblatt, Standardizing immunophenotyping for the Human Immunology Project Nature Reviews Immunology. ,vol. 12, pp. 191- 200 ,(2012) , 10.1038/NRI3158
Yoichi Maekawa, Chieko Ishifune, Shin-ichi Tsukumo, Katsuto Hozumi, Hideo Yagita, Koji Yasutomo, Notch controls the survival of memory CD4+ T cells by regulating glucose uptake. Nature Medicine. ,vol. 21, pp. 55- 61 ,(2015) , 10.1038/NM.3758
Christian S. Hinrichs, Zachary A. Borman, Luca Gattinoni, Zhiya Yu, William R. Burns, Jianping Huang, Christopher A. Klebanoff, Laura A. Johnson, Sid P. Kerkar, Shicheng Yang, Pawel Muranski, Douglas C. Palmer, Christopher D. Scott, Richard A. Morgan, Paul F. Robbins, Steven A. Rosenberg, Nicholas P. Restifo, Human effector CD8+ T cells derived from naive rather than memory subsets possess superior traits for adoptive immunotherapy Blood. ,vol. 117, pp. 808- 814 ,(2011) , 10.1182/BLOOD-2010-05-286286
Raul Vizcardo, Kyoko Masuda, Daisuke Yamada, Tomokatsu Ikawa, Kanako Shimizu, Shin-ichiro Fujii, Haruhiko Koseki, Hiroshi Kawamoto, Regeneration of Human Tumor Antigen-Specific T Cells from iPSCs Derived from Mature CD8+ T Cells Cell Stem Cell. ,vol. 12, pp. 31- 36 ,(2013) , 10.1016/J.STEM.2012.12.006
Kim C. Ohaegbulam, Amer Assal, Eszter Lazar-Molnar, Yu Yao, Xingxing Zang, Human cancer immunotherapy with antibodies to the PD-1 and PD-L1 pathway Trends in Molecular Medicine. ,vol. 21, pp. 24- 33 ,(2015) , 10.1016/J.MOLMED.2014.10.009