Cytoskeletal mechanisms responsible for invasive migration of neoplastic cells.

摘要: Cytoskeletal reorganizations, especially alterations of contractile tension generated by the actin-myosin cortex, are central importance in development phenotype morphologically transformed neoplastic cells with invasive behavior. These reorganizations can be regarded as genetically determined aberrations physiological reactions normal which responsible for their ability to undergo exploratory migrations, including epithelio-mesenchymal transformations, invasion matrix epithelial tubules etc. It is suggested that these and transformations based on Rho-dependent contractility. A decrease or an increase contractility may result distinct types phenotypes. contractility-dependent modified expression other genes, those coding components adhesive structures.