Immune (T cell) response in viral hepatitis

摘要: The immune system is of central importance in the course viral diseases and increasing evidence suggests that this also true for hepatitis B C. On one hand responses to antigens are believed be responsible clearance acute C, on other hand, if they fail eliminate or control virus, most likely cause chronic inflammatory liver disease. uncompromised human equipped with humoral cellular components, infections can virus at least achieve control. In natural hepatitis, however, persistence infecting common numerous observations suggest both host factors may contribute persistence. Since HBV HCV non-cytopathic viruses, tissue damage result a permanent process within mediated by effector cells which obviously cannot virus-infected hepatocytes therefore terminate infection. decisive role becomes evident C infection when infected holds key decide whether there will self-limited disease hepatitis. Although displays similar features not only virologically important differences infections. infection, healthy adults, minority (5-10%) individuals develop majority run an asymptomatic about 85% progress Only those patients who display symptomatic clear 50%, suggesting vigorous response contributes these patients.