The Cellular Immunotherapy Revolution: Arming the Immune System for Precision Therapy

摘要: Immunotherapy treatments harnessing the patient's immune system herald a new era of personalized medicine, offering hope for curative responses in patients with serious illnesses. Cell-mediated immunity can eliminate cancer cells and provide durable remissions. This often relies on repurposing cytotoxic T cell activity through modified receptors or chimeric antigen receptors. Furthermore, synthetic biology has expanded engineering toolkit to more functionality, including disease targeting, potency, safety. We focus cell-based immunotherapy, highlighting discoveries genetic therapeutic use. also examine emerging paths that could be undertaken improve this novel class drugs, discuss challenges toxicities as well other limitations cellular immunotherapy.