Exercise as a provocative test in early renal disease in type 1 (insulin-dependent) diabetes: albuminuric, systemic and renal haemodynamic responses.

摘要: The value of exercise as a provocative test for early renal disease in Type 1 (insulin-dependent) diabetes was reevaluated. Three carefully characterized groups males were studied: 10 non-diabetic controls, 16 diabetic patients (group 1) with normal urinary albumin excretion (< 15 μg/min) and 14 Albustix-negative diabetics 2) increased (15–122 μg/min). Assignment to study group made on the basis three 24-h urine collections, well matched age, weight, height, serum creatinine concentration. two similar regard duration (13±6 versus 16±3 years), metabolic control (HbA1c: 8.4±1.4 8.7±1.3%) degree complications (beat-to-beat variation retinopathy). An protocol 450 600 kpm/min workloads employed. In resting state 2 had elevated systolic blood pressure compared subjects (132±13 119±9 mmHg), their glomerular filtration rate significantly reduced (123±19 138±15ml/min per 1.73m2, p < 0.05). During all (normal subjects: 6±0.7 8±1.3 (μg/min); 1: 6±0.6 9±1 μg/min 2: 48±10 113±23 μg/min), relative increase being higher (p 0.01). changes systemic haemodynamics spite maximum working capacity (949±249 1:1163±200 1267±264 haemodynamic qualitatively groups, but fraction during almost identical values than + 0.29±0.02 0.26±0.03, 0.02). These findings suggest that an transcapillary gradient, obtained moderate exercise, will not cause abnormal se. A functional lesion, already recognisable at rest (elevated excretion) must also be present.