Shadoo ( Sprn ) and prion disease incubation time in mice
作者： Sarah E. Lloyd , Julia Grizenkova , Hirva Pota , John Collinge
DOI: 10.1007/S00335-009-9194-5
关键词: Gene expression 、 Incubation 、 Virology 、 Scrapie 、 Bovine spongiform encephalopathy 、 Gene 、 Untranslated region 、 Incubation period 、 Open reading frame 、 Biology
摘要: Prion diseases are transmissible neurodegenerative disorders of mammalian species and include scrapie, bovine spongiform encephalopathy (BSE), variant Creutzfeldt-Jakob disease (vCJD). The prion protein (PrP) plays a key role in the disease, with coding polymorphism both human mouse influencing susceptibility incubation time, respectively. Other genes also thought to be important plausible candidate is Sprn, which encodes PrP-like Shadoo (Sho). Sho expressed adult central nervous system exhibits neuroprotective activity reminiscent PrP an vitro assay. To investigate Sprn time we sequenced open reading frame (ORF) diverse panel mice saw little variation except strains derived from wild-trapped mice. Sequencing untranslated regions revealed polymorphisms that allowed us carry out association study period Northport heterogeneous stock inoculated Chandler/RML prions. We examined expression level mRNA brains normal prion-infected no correlation either genotype or time. therefore conclude does not play major these
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paperity.org参考文章(34)
Doron Shmerling, Ivan Hegyi, Marek Fischer, Thomas Blättler, Sebastian Brandner, Jürgen Götz, Thomas Rülicke, Eckhard Flechsig, Antonio Cozzio, Christian von Mering, Christoph Hangartner, Adriano Aguzzi, Charles Weissmann, Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions. Cell. ,vol. 93, pp. 203- 214 ,(1998) , 10.1016/S0092-8674(00)81572-X
S. E. Lloyd, O. N. Onwuazor, J. A. Beck, G. Mallinson, M. Farrall, P. Targonski, J. Collinge, E. M. C. Fisher, Identification of multiple quantitative trait loci linked to prion disease incubation period in mice Proceedings of the National Academy of Sciences of the United States of America. ,vol. 98, pp. 6279- 6283 ,(2001) , 10.1073/PNAS.101130398
Simon Mead, Michael PH Stumpf, Jerome Whitfield, Jonathan A Beck, Mark Poulter, Tracy Campbell, James B Uphill, David Goldstein, Michael Alpers, Elizabeth MC Fisher, John Collinge, Balancing selection at the prion protein gene consistent with prehistoric kurulike epidemics. Science. ,vol. 300, pp. 640- 643 ,(2003) , 10.1126/SCIENCE.1083320
J A Beck, T A Campbell, G Adamson, M Poulter, J B Uphill, E Molou, J Collinge, S Mead, Association of a null allele of SPRN with variant Creutzfeldt–Jakob disease Journal of Medical Genetics. ,vol. 45, pp. 813- 817 ,(2008) , 10.1136/JMG.2008.061804
G A Carlson, P A Goodman, M Lovett, B A Taylor, S T Marshall, M Peterson-Torchia, D Westaway, S B Prusiner, Genetics and polymorphism of the mouse prion gene complex: control of scrapie incubation time. Molecular and Cellular Biology. ,vol. 8, pp. 5528- 5540 ,(1988) , 10.1128/MCB.8.12.5528
D Botstein, E S Lander, MAPPING MENDELIAN FACTORS UNDERLYING QUANTITATIVE TRAITS USING RFLP LINKAGE MAPS Genetics. ,vol. 121, pp. 185- 199 ,(1989) , 10.1093/GENETICS/121.1.185
John Collinge, Prion Diseases of Humans and Animals: Their Causes and Molecular Basis Annual Review of Neuroscience. ,vol. 24, pp. 519- 550 ,(2001) , 10.1146/ANNUREV.NEURO.24.1.519
R Hitzemann, B Hitzemann, S Kanes, K Dains, Further studies on the relationship between dopamine cell density and haloperidol-induced catalepsy. Journal of Pharmacology and Experimental Therapeutics. ,vol. 271, pp. 969- 976 ,(1994)
R Nakaoke, S Katamine, K Shigematsu, S B Prusiner, N Nishida, R Atarashi, S P Erpel, S J DeArmond, C Petromilli, S Sakaguchi, M Torchia, P Tremblay, S Shirabe, T Houtani, T Sugimoto, A mouse prion protein transgene rescues mice deficient for the prion protein gene from Purkinje cell degeneration and demyelination Laboratory Investigation. ,vol. 79, pp. 689- 697 ,(1999)
S. B. Prusiner, D. P. Stites, Robert N Hogan, J. D. Watson, D. T. Kingsbury, K. C. Kasper, Genetic control of scrapie and Creutzfeldt-Jakob disease in mice. Journal of Immunology. ,vol. 131, pp. 491- 496 ,(1983)