Proton MR Spectroscopy in Infants with Cerebral Energy Deficiency due to Hypoxia and Metabolic Disorders
作者： H. Kugel , W. Heindel , B. Roth , S. Ernst , K. Lackner
DOI: 10.3109/02841859809175502
关键词: Hypoxia (medical) 、 Metabolism 、 Asphyxia 、 Nuclear magnetic resonance 、 Oxidative phosphorylation 、 Internal medicine 、 Enzyme 、 Endocrinology 、 Trimethylamine 、 In vivo magnetic resonance spectroscopy 、 Medicine 、 Basal ganglia
摘要: Purpose: To investigate the similarities and differences of cellular energy deficiencies due to asphyxia impaired oxidative phosphorylation caused by enzyme using localized 1H-MR spectroscopy brain.Material Methods: In 35 neonates infants with a postconceptional age 36.4–153 weeks, spectra were obtained from basal ganglia. children, 14 served as control group, 12 suffered hypoxicischemic disease (HIE), 9 had congenital enzymatic disorders.Results: Eleven children HIE showed low n-acetyl aspartate (NAA) trimethylamine (TMA) ratios, indicating neuronal damage. Lactate (Lac) TMA ratios correlated grade. Children disorders metabolism NAA/TMA ranging severely decreased normal, but 7 high Lac signals, even in brains normal NAA/TMA.Conclusion: High Lac/TMA deficiencies, contrast that cor...
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