Using stem cells to produce insulin

摘要: Introduction: Tremendous progress has been made in generating insulin-producing cells from pluripotent stem cells. The best outcome of the refined protocols became apparent first clinical trial announced by ViaCyte, based on implantation pancreatic progenitors that would further mature into functional inside patient’s body.Areas covered: Several groups, including ours, have contributed to improve strategies generate Of note, latest results gained a substantial amount interest as method create potentially and limitless supply β-cell revert diabetes mellitus. This review analyzes accomplishments taken place over last few decades, summarizes state-of-art methods for replacement therapies differentiation embryonic glucose-responsive dish discusses alternative approaches obtain new sources insulin-produc...