Transcriptome Sequencing to Detect the Potential Role of Long Noncoding RNAs in Salt-Sensitive Hypertensive Rats.
作者： Hao Wu , Sibo Zhu , Rui Yuan , Yang Yi , Hanqing Wang
DOI: 10.1155/2019/2816959
关键词: Sodium 、 Urinary system 、 Gene 、 Blood pressure 、 RNA 、 Endocrinology 、 Exome sequencing 、 Biology 、 Renal medulla 、 Creatinine 、 Internal medicine
摘要: Backgrounds. Long noncoding RNAs (lncRNAs) play an important role in various biological processes. However, their functions salt-sensitive hypertension are largely unknown. In this study, the lncRNA-seq technique was employed to compare expression profiles of lncRNAs and mRNAs hypertensive rats. Methods. Blood pressure, serum sodium, urinary creatinine were texted salt-insensitive rats fed with different salt concentrations. High-throughput sequencing used detect mRNA renal medulla two groups. Results. pressure sodium/creatinine high-salt diets sensitive group significantly higher than that control group. Serum sodium has no significant difference between groups diets. NONRATG007131.2 NONRATG012674.2 most high Correlation analysis reveals Matn1, Serpinb12, Anxa8, Hspa5 may hypertension. Conclusion. This study analyzed lncRNA by high-throughput sequencing. Salt sensitivity concentration key factors for induction We found some potential genes
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