IL-27-induced modulation of autoimmunity and its therapeutic potential
作者： Rakeshchandra R Meka , Shivaprasad H Venkatesha , Steven Dudics , Bodhraj Acharya , Kamal D Moudgil
DOI: 10.1016/J.AUTREV.2015.08.001
关键词: Immune system 、 FOXP3 、 T cell 、 Cellular differentiation 、 Systemic lupus erythematosus 、 Autoimmunity 、 Biology 、 Antigen-presenting cell 、 Immunology 、 Arthritis
摘要: Interleukin-27 (IL-27) is a new member of the IL-12 family. It produced by activated antigen-presenting cells and plays an important role in regulation CD4+ T cell differentiation immune response. IL-27 activates multiple signaling cascades, including JAK-STAT p38 MAPK pathways. Several studies have revealed that promotes Th1 Tr1, but inhibits Th2, Th17, Treg cells. However, few shown opposite effect on certain subsets, such as Treg. displays both pro- anti- inflammatory activities different autoimmune diseases. Here, we discussed rheumatoid arthritis, sclerosis, colitis, lupus, psoriasis, type 1 diabetes, uveitis. Most this information derived from experimental models these The mechanistic basis dual inflammation autoimmunity still not fully defined. In general, pro-/anti-inflammatory activity influenced underlying effector pathways, phase disease, presence or absence counter-regulatory cytokines/T tissue/cell under study. Despite spectrum outcomes various diseases, mostly anti-inflammatory immunomodulatory effects been observed category Accordingly, represents novel, promising target/agent for treatment
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