A novel mutant phenotype implicates dicephalic in cyst formation in the Drosophila ovary

作者: Ruth McCaffrey , Daniel St Johnston , Acaimo González-Reyes

DOI: 10.1002/DVDY.20620

关键词: MutantOocyteCell biologyKaryosome formationSomatic cellBiologyGermlineMeiosisGeneticsOogenesisPhenotype

摘要: The establishment of polarity in Drosophila requires the correct specification oocyte early stages oogenesis, its positioning at posterior egg chamber, and signalling events between adjacent follicle cells. As a consequence, anterior-posterior dorsal-ventral axes are fixed. localisation depends on cadherin-mediated adhesion Here we show that dicephalic mutants affect without interfering with germarium. Unlike other also placement oocyte, neither gurken expression nor karyosome formation during meiosis. By analysing detail mutant phenotypes dicephalic, find cyst germaria is defective it shares some similarities cysts lack DE-cadherin germline We propose model which involved proper somatic

参考文章(56)
Seth D Findley, Mio Tamanaha, Nigel J Clegg, Hannele Ruohola-Baker, Maelstrom, a Drosophila spindle-class gene, encodes a protein that colocalizes with Vasa and RDE1/AGO1 homolog, Aubergine, in nuage. Development. ,vol. 130, pp. 859- 871 ,(2003) , 10.1242/DEV.00310
Uri Abdu, Michael Brodsky, Trudi Schüpbach, Activation of a meiotic checkpoint during Drosophila oogenesis regulates the translation of Gurken through Chk2/Mnk. Current Biology. ,vol. 12, pp. 1645- 1651 ,(2002) , 10.1016/S0960-9822(02)01165-X
Michael Bate, Alfonso Martinez Arias, The development of Drosophila melanogaster Cold Spring Harbor Laboratory Press. ,(2009)
Sandra Orsulic, Eric Wieschaus, Dari Sweeton, Mark Peifer, A role for the Drosophila segment polarity gene armadillo in cell adhesion and cytoskeletal integrity during oogenesis Development. ,vol. 118, pp. 1191- 1207 ,(1993)
Sylvia Styhler, Paul Lasko, Beat Suter, Akira Nakamura, Andrew Swan, vasa is required for GURKEN accumulation in the oocyte, and is involved in oocyte differentiation and germline cyst development Development. ,vol. 125, pp. 1569- 1578 ,(1998) , 10.1242/DEV.125.9.1569
Casimiro Castillejo-López, Wilma Martinez Arias, Stefan Baumgartner, The fat-like gene of drosophila is the true orthologue of vertebrate fat cadherins and is involved in the formation of tubular organs. Journal of Biological Chemistry. ,vol. 279, pp. 24034- 24043 ,(2004) , 10.1074/JBC.M313878200