作者: Scott M. Grundy , Ivor J. Benjamin , Gregory L. Burke , Alan Chait , Robert H. Eckel
DOI: 10.1161/01.CIR.100.10.1134
关键词: Obesity 、 Heart disease 、 Insulin resistance 、 Type 2 diabetes 、 Metabolic syndrome 、 Diabetes mellitus 、 Internal medicine 、 Medicine 、 Impaired fasting glucose 、 Insulin
摘要: This statement examines the cardiovascular complications of diabetes mellitus and considers opportunities for their prevention. These include coronary heart disease (CHD), stroke, peripheral arterial disease, nephropathy, retinopathy, possibly neuropathy cardiomyopathy. Because aging population an increasing prevalence obesity sedentary life habits in United States, is increasing. Thus, must take its place alongside other major risk factors as important causes (CVD). In fact, from point view medicine, it may be appropriate to say, “diabetes a disease.” The most prevalent form type 2 diabetes. disorder typically makes appearance later life. The underlying metabolic are combination impairment insulin-mediated glucose disposal (insulin resistance) defective secretion insulin by pancreatic β-cells. Insulin resistance develops physical inactivity, acting on substrate genetic susceptibility.1 declines with advancing age,3 4 this decline accelerated factors.5 6 precedes onset commonly accompanied factors: dyslipidemia, hypertension, prothrombotic factors.7 8 common clustering these single individual has been called syndrome. Many patients syndrome manifest impaired fasting (IFG)9 even when they do not have overt mellitus.10 development many years11 ; great importance, that constitute contribute independently CVD risk. Recently, new criteria accepted diagnosis diabetes.9 upper threshold plasma …