Diabetes and cardiovascular disease : A statement for healthcare professionals from the American heart association

作者: Scott M. Grundy , Ivor J. Benjamin , Gregory L. Burke , Alan Chait , Robert H. Eckel

DOI: 10.1161/01.CIR.100.10.1134

关键词: ObesityHeart diseaseInsulin resistanceType 2 diabetesMetabolic syndromeDiabetes mellitusInternal medicineMedicineImpaired fasting glucoseInsulin

摘要: This statement examines the cardiovascular complications of diabetes mellitus and considers opportunities for their prevention. These include coronary heart disease (CHD), stroke, peripheral arterial disease, nephropathy, retinopathy, possibly neuropathy cardiomyopathy. Because aging population an increasing prevalence obesity sedentary life habits in United States, is increasing. Thus, must take its place alongside other major risk factors as important causes (CVD). In fact, from point view medicine, it may be appropriate to say, “diabetes a disease.” The most prevalent form type 2 diabetes. disorder typically makes appearance later life. The underlying metabolic are combination impairment insulin-mediated glucose disposal (insulin resistance) defective secretion insulin by pancreatic β-cells. Insulin resistance develops physical inactivity, acting on substrate genetic susceptibility.1 declines with advancing age,3 4 this decline accelerated factors.5 6 precedes onset commonly accompanied factors: dyslipidemia, hypertension, prothrombotic factors.7 8 common clustering these single individual has been called syndrome. Many patients syndrome manifest impaired fasting (IFG)9 even when they do not have overt mellitus.10 development many years11 ; great importance, that constitute contribute independently CVD risk. Recently, new criteria accepted diagnosis diabetes.9 upper threshold plasma …

参考文章(110)
Derek LeRoith, Simeon I Taylor, Jerrold M Olefsky, None, Diabetes mellitus : a fundamental and clinical text Lippincott Williams & Wilkins. ,(2004)
Robert Hardin Williams, Henry Kronenberg, Williams Textbook of Endocrinology ,(2011)
R Andres, D C Muller, D Elahi, J D Tobin, The effect of age on insulin resistance and secretion: a review. Seminars in Nephrology. ,vol. 16, pp. 289- 298 ,(1996)
Donald J. Chisholm, Lesley V. Campbell, Edward W. Kraegen, PATHOGENESIS OF THE INSULIN RESISTANCE SYNDROME (SYNDROME X) Clinical and Experimental Pharmacology and Physiology. ,vol. 24, pp. 782- 784 ,(1997) , 10.1111/J.1440-1681.1997.TB02132.X
Mahmoud A. Mahgoub, Anwar S. Abd-Elfattah, Diabetes mellitus and cardiac function Molecular and Cellular Biochemistry. ,vol. 180, pp. 59- 64 ,(1998) , 10.1007/978-1-4615-5687-9_6
R. D. Lindeman, L. J. Romero, R. Hundley, A. S. Allen, H. C. Liang, R. N. Baumgartner, K. M. Koehler, D. S. Schade, P. J. Garry, Prevalences of Type 2 Diabetes, the Insulin Resistance Syndrome, and Coronary Heart Disease in an Elderly, Biethnic Population Diabetes Care. ,vol. 21, pp. 959- 966 ,(1998) , 10.2337/DIACARE.21.6.959