Plasticity of PDZ domains in ligand recognition and signaling.

摘要: The PDZ domain is a protein–protein interacting module that plays an important role in the organization of signaling complexes. recognition short intrinsically disordered C-terminal peptide motifs archetypical function, but functional repertoire this versatile also includes internal sequences, dimerization and phospholipid binding. function can be tuned by various means such as allosteric effects, changes physiological buffer conditions phosphorylation domains and/or ligands, which poses dynamic regulators cell signaling. This review focused on plasticity interactions.