Urodynamics and bladder muscarinic receptors in rats with cerebral infarction and bladder outlet obstruction.
作者： Shuji Maruyama , Souhei Kurosawa , Yukiko Takagi , Tomomi Oki , Yukiko Noguchi
DOI: 10.1016/J.NEULET.2006.12.048
关键词: Muscarinic Receptor Binding 、 Muscarinic acetylcholine receptor 、 Cerebral infarction 、 Infarction 、 Vascular disease 、 Central nervous system disease 、 Urination 、 Bladder outlet obstruction 、 Internal medicine 、 Endocrinology 、 Medicine
摘要: We characterized muscarinic receptor binding and urodynamic parameters in rats with cerebral infarction chronic bladder outlet obstruction as models of detrusor overactivity. Bladder weight showed little significant difference between the cerebral-infarcted sham rats, but was about three times greater outlet-obstructed rats. capacity voided volume were significantly lower (36.7 55.1%, respectively) than Involuntary contractions before micturition seen not The increases (2.65 2.57 times, volume, compared those Bmax values for specific [N-methyl-3H]scopolamine ([3H]NMS) (34%) increased whereas Kd unaffected by infarction. On other hand, there change [3H]NMS bladder-obstructed In conclusion, present study shows that causes up-regulation receptors, such regulation receptors may be at least partly associated symptoms overactivity subsequent to
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