MicroRNA expression patterns in oral squamous cell carcinoma: hsa-mir-99b-3p and hsa-mir-100-5p as novel prognostic markers for oral cancer.

摘要: BACKGROUND MicroRNAs (miRNA) recently evolved as potential cancer biomarkers. Therefore, the aim of present study was to evaluate prognostic impact eight miRNAs connected oral squamous cell carcinoma (OSCC). METHOD Expression levels hsa-mir-21-5p, hsa-mir-29b-3p, hsa-mir-31-5p, hsa-mir-99a-5p, hsa-mir-99b-3p, hsa-mir-100-5p, hsa-mir-143-3p and hsa-mir-155-5p were analyzed in tumor tissue (n = 36) healthy mucosal (n = 17) correlated with clinical variables. Results cohort validated an OSCC The Cancer Genome Atlas. RESULTS Increased hsa-mir-99b-3p expression level showed a tendency toward advanced stages, high hsa-mir-100-5p associated extracapsular extension. While better survival, poorer survival cohort. CONCLUSION Our results indicate that may serve novel biomarkers OSCC.