Regulation of macrophage populations. II. Synthesis and expression of Ia antigens by peritoneal exudate macrophages is a transient event.

摘要: We have evaluated the biosynthesis and surface expression of I-A antigens by peritoneal macrophages found that both events terminated during 1st day in culture, contrast to undiminished synthesis H-2K antigens. This pattern was observed regardless means which were elicited, but subject modulation for a limited period time vitro: phagocytic stimuli able augment expression. The loss re-expression after phagocytosis reflected stimulatory capacity these mixed leukocyte reaction. Moreover, we I-A-bearing lost from exudate vivo irradiation. Our data suggest that, as vitro, this phenomenon is due transition individual I-A-positive I-A-negative, constant renewal required maintain subset vivo.