Macrophage heterogeneity in receptor activity: the activation of macrophage Fc receptor function in vivo and in vitro.

摘要: The Fc receptor activity of single macrophages and distinct macrophage populations was examined in terms cellular avidity for IgG antibody by using a rosette assay which permits characterization at the level quantitation any changes such activity. Marked heterogeneity shown to exist within normal macrophages. Both peritoneal alveolar exhibit or logistic distribution avidities antibody. mean population, however, found be approximately 3 times greater than that population. Moreover, possess range Comparison unstimulated induced inflammatory exudate revealed 6-fold increase proportion high cells latter Normal were undergo striking vitro. Under certain conditions culture these acquire antibody-binding capacity characteristic Fresh guinea pig serum prevent this activation function Aged somewhat less effective. factor(s) responsible appears consumed exhausted some way It is heat stable has molecular weight 100,000 daltons. Serum not involved effects fresh on described here may facilitate both presentation antigen specific T lymphocytes dependent killing tumor Changes kind thus play an important regulatory role induction immune response effector mechanisms immunologic surveillance.