Hunting down factor VIII in the immunopeptidome

摘要: Major histocompatibility complex class II (MHCII)-restricted peptide presentation is crucial for the selection and subsequent proliferation of antigen specific CD4+ T cells. While antigen-specific cells beneficial in context vaccination, emergence following administration therapeutic proteins like factor VIII (FVIII) not desirable. The mechanism uptake, processing FVIII by antigen-presenting (APCs) has been subject intense study over past 10 years. Multiple receptors have implicated uptake APCs. A determinant directing its entry APCs resides C1 domain FVIII. Until recently, our knowledge on repertoire derived presented MHCII was limited. Peptide sequences recognized identified using tetramers as well directly monitoring peptide-induced More naturally peptides from pulsing immature dendritic with In a complementary approach HLA-DRB1(∗)15 transgenic mice were used to identify restricted reactive towards human this review we summarize current that are discuss relevance these findings etiology inhibitor development patients hemophilia A.