p53 and c-erbB-2 as markers of resistance to adjuvant chemotherapy in breast cancer.

摘要: Recent literature suggests that c-erbB-2 and p53 alteration might be linked to drug resistance. This study investigates the relation of oncoprotein overexpression protein accumulation with prognosis in patients node-positive breast cancer (NPBC) assesses modifying effect these markers on response short (1-10 courses) or prolonged (> 10 adjuvant chemotherapy. is based 458 NPBC diagnosed from 1980 1986, an average years follow-up. Marker expression was evaluated by immunohistochemical analysis formalin-fixed, paraffin-embedded material antibodies p53. expressed 17.2% cases, 19.1% tumors stained positively for By multivariate analysis, women chemotherapy had better survival than those a course among whose tumor lacked (P = .0245) .0477). Prolonged chemotherapy, however, associated little no change markers. The present adds support hypothesis linking