Costs and trends in pancreatic cancer treatment

作者: Caitriona B. O'Neill , Coral L. Atoria , Eileen M. O'Reilly , Jennifer LaFemina , Martin C. Henman

DOI: 10.1002/CNCR.27490

关键词: MedicineRetrospective cohort studySurveillance, Epidemiology, and End ResultsEpidemiologyHealth careCohortCancerEmergency medicinePancreatic cancerPopulationIntensive care medicine

摘要: BACKGROUND: Pancreatic cancer poses a substantial morbidity and mortality burden in the United States, predominantly affects older adults. The objective of this study was to estimate direct medical costs pancreatic treatment population-based cohort Medicare beneficiaries, contribution different modalities health care services total cost trends over time. METHODS: In linked Surveillance, Epidemiology, End Results (SEER)-Medicare database, patients were identified who aged 66 years or diagnosed from 2000 2007. Total estimated payments overall within categories care. Costs attributable by subtracting matched cancer-free beneficiaries. RESULTS: A 15,037 identified, whom 97% observed diagnosis until death. Mean $65,500. greater for with resectable locoregional disease ($134,700) than those unresectable distant ($65,300 $49,000, respectively). Hospitalizations cancer-directed procedures collectively accounted largest fraction costs. appeared increase slightly period (P = .05). mean $61,700. CONCLUSIONS: Despite poor prognosis short survival, economic elderly is substantial. Demographic trends, use targeted therapies, possible implementation screening strategies are likely impact patterns future. Cancer 2012. © 2012 American Society.

参考文章(48)
B. Topal, G. Peeters, H. Vandeweyei, R. Aerts, F. Penninckx, Hospital cost-categories of pancreaticoduodenectomy. Acta Chirurgica Belgica. ,vol. 107, pp. 373- 377 ,(2007) , 10.1080/00015458.2007.11680078
Brandabur Jj, Kozarek Ra, Ryan Ja, Lewis Gp, Ball Tj, Hofer Bo, Freeny Pc, Traverso Lw, Nonoperative versus operative treatment of obstructive jaundice in pancreatic cancer: cost and survival analysis. The American Journal of Gastroenterology. ,vol. 83, pp. 1132- 1139 ,(1988)
Mark S. Lea, LeRoy H. Stahlgren, Is resection appropriate for adenocarcinoma of the pancreas?: A cost-benefit analysis☆ American Journal of Surgery. ,vol. 154, pp. 651- 654 ,(1987) , 10.1016/0002-9610(87)90236-4
Gudjonsson B, Carcinoma of the pancreas: critical analysis of costs, results of resections, and the need for standardized reporting. Journal of The American College of Surgeons. ,vol. 181, pp. 483- 503 ,(1995)
Florence K. Tangka, Justin G. Trogdon, Lisa C. Richardson, David Howard, Susan A. Sabatino, Eric A. Finkelstein, Cancer treatment cost in the United States: has the burden shifted over time? Cancer. ,vol. 116, pp. 3477- 3484 ,(2010) , 10.1002/CNCR.25150
Jonas Hjelmgren, Jeanette Ceberg, Ulf Persson, Thor A. Alvegård, The cost of treating pancreatic cancer--a cohort study based on patients' records from four hospitals in Sweden. Acta Oncologica. ,vol. 42, pp. 218- 226 ,(2003) , 10.1080/02841860310000386
Kristin M. Sheffield, Casey A. Boyd, Jamie Benarroch-Gampel, Yong-Fang Kuo, Catherine D. Cooksley, Taylor S. Riall, End-of-Life Care in Medicare Beneficiaries Dying with Pancreatic Cancer Cancer. ,vol. 117, pp. 5003- 5012 ,(2011) , 10.1002/CNCR.26115
B. Glimelius, K. Hoffman, W. Graf, U. Haglund, O. Nyrén, L. Páhlman, P.-O. Sjödén, Cost-effectiveness of palliative chemotherapy in advanced gastrointestinal cancer Annals of Oncology. ,vol. 6, pp. 267- 274 ,(1995) , 10.1093/OXFORDJOURNALS.ANNONC.A059157
Rebecca A. Miksad, Lowell Schnipper, Michael Goldstein, Does a statistically significant survival benefit of erlotinib plus gemcitabine for advanced pancreatic cancer translate into clinical significance and value Journal of Clinical Oncology. ,vol. 25, pp. 4506- 4507 ,(2007) , 10.1200/JCO.2007.13.0401
Martin L. Brown, Gerald F. Riley, Nicki Schussler, Ruth Etzioni, Estimating health care costs related to cancer treatment from SEER-Medicare data. Medical Care. ,vol. 40, ,(2002) , 10.1097/00005650-200208001-00014