The Stress-Sensing TORC2 Complex Activates Yeast AGC-Family Protein Kinase Ypk1 at Multiple Novel Sites.

作者: Kristin L. Leskoske , Françoise M. Roelants , Maria Nieves Martinez Marshall , Jennifer M. Hill , Jeremy Thorner

DOI: 10.1534/GENETICS.117.1124

关键词: GeneticsMutantFunction (biology)BiochemistryProtein kinase ACellPhosphorylationYeastBiologyMutationSaccharomyces cerevisiae

摘要: Yeast (Saccharomyces cerevisiae) target of rapamycin (TOR) complex 2 (TORC2) is a multi-subunit plasma membrane-associated protein kinase and vital growth regulator. Its essential …

参考文章(83)
Christl Gaubitz, Taiana M. Oliveira, Manoel Prouteau, Alexander Leitner, Manikandan Karuppasamy, Georgia Konstantinidou, Delphine Rispal, Sandra Eltschinger, Graham C. Robinson, Stéphane Thore, Ruedi Aebersold, Christiane Schaffitzel, Robbie Loewith, Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2 Molecular Cell. ,vol. 58, pp. 977- 988 ,(2015) , 10.1016/J.MOLCEL.2015.04.031
Fred Sherman, Gerald R. Fink, James B. Hicks, Laboratory course manual for methods in yeast genetics Cold Spring Harbor Laboratory. ,(1986)
Sandra Eltschinger, Robbie Loewith, TOR Complexes and the Maintenance of Cellular Homeostasis Trends in Cell Biology. ,vol. 26, pp. 148- 159 ,(2016) , 10.1016/J.TCB.2015.10.003
Stephen B. Helliwell, Michael N. Hall, Isabelle Howald, Nik Barbet, TOR2 Is Part of Two Related Signaling Pathways Coordinating Cell Growth in Saccharomyces cerevisiae Genetics. ,vol. 148, pp. 99- 112 ,(1998) , 10.1093/GENETICS/148.1.99
Nobuyasu Ikai, Norihiko Nakazawa, Takeshi Hayashi, Mitsuhiro Yanagida, The reverse, but coordinated, roles of Tor2 (TORC1) and Tor1 (TORC2) kinases for growth, cell cycle and separase-mediated mitosis in Schizosaccharomyces pombe. Open Biology. ,vol. 1, pp. 110007- 110007 ,(2011) , 10.1098/RSOB.110007
Baoguang Zhao, Ruth Lehr, Angela M. Smallwood, Thau F. Ho, Kathleen Maley, Tanya Randall, Martha S. Head, Kristin K. Koretke, Christine G. Schnackenberg, Crystal structure of the kinase domain of serum and glucocorticoid-regulated kinase 1 in complex with AMP–PNP Protein Science. ,vol. 16, pp. 2761- 2769 ,(2007) , 10.1110/PS.073161707
Antonio Casamayor, Pamela D. Torrance, Takayasu Kobayashi, Jeremy Thorner, Dario R. Alessi, Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast Current Biology. ,vol. 9, pp. 186- 197 ,(1999) , 10.1016/S0960-9822(99)80088-8
Michiko MOMOI, Daisuke TANOUE, Yidi SUN, Hiromu TAKEMATSU, Yusuke SUZUKI, Minoru SUZUKI, Akemi SUZUKI, Tetsuro FUJITA, Yasunori KOZUTSUMI, SLI1 (YGR212W) is a major gene conferring resistance to the sphingolipid biosynthesis inhibitor ISP-1, and encodes an ISP-1 N-acetyltransferase in yeast Biochemical Journal. ,vol. 381, pp. 321- 328 ,(2004) , 10.1042/BJ20040108
Harald W Platta, Harald Stenmark, Endocytosis and signaling. Current Opinion in Cell Biology. ,vol. 23, pp. 393- 403 ,(2011) , 10.1016/J.CEB.2011.03.008