In Vivo MRS of Lipids in Adipose Tissue, Bone Marrow, and Liver

摘要: For a long time, adipose tissue attracted little interest for in vivo studies using magnetic resonance, as it seemed not to be directly involved most diseases. The past few years have revealed significant correlations between the distribution and composition of body development metabolic In addition, fatty components parenchymal organs such liver, pancreas, musculature (the so-called ectopic fat) growing medical research. T1-weighted fat selective imaging provides reliable overview various parts. Modern also reveals concentrations liver other organs, detectable at lipid about 2% by volume. crucial role localized 1H-MRS today is assessment storage fat, especially determining proportions monounsaturated acids (MUFA) polyunsaturated (PUFA). Another advantage 1H spectroscopy over MRI techniques its sensitivity low fractions lipids organs. This feature paves way short-term noninvasive interventional (nutrition, exercise, or medication), MRS monitor their effects on concentrations. Sensitive measurements small shifts water portions hematopoietic red bone marrow might help staging blood disorders monitoring related treatment. Keywords: 1H spectroscopy; adipose tissue; adipose composition; obesity; visceral tissue; bone marrow; leukemia; stem cell transplantation; liver steatosis; non-alcoholic disease (NAFLD); non-alcoholic steatohepatitis (NASH)