In Vitro and In Vivo Study of Argyreia speciosa on Chronic Gastric Ulceration and Metabolic Studies
作者： Lubna Azmi , Ila Shukla , Shyam Sundar Gupta , Narayan Prasad Yadav , Padam Kant
DOI: 10.1007/S40011-018-1023-8
关键词: Cancer 、 Pharmacology 、 Gastrointestinal disorder 、 In vitro 、 Antagonist 、 Histamine H2 receptor 、 Argyreia 、 In vivo 、 Antioxidant 、 Medicine 、 General Agricultural and Biological Sciences 、 General Environmental Science
摘要: Chronic gastric ulcer being the most prevalent gastrointestinal disorder is considered a major cause of cancer. Large numbers synthetic drugs ranging from proton-pump inhibitors and H2 receptor antagonist to cytoprotective agents are available, but they have side effects. Inadequacy these forces develop new herbal-based active against chronic ulcer. In present study, antiulcer activity butanolic extract Argyreia speciosa Linn. f., Sweet: Family Convolvulaceae (b-ASL) was investigated acetic-acid-induced rat models. The effect different dose A. studied for antioxidant, anti-secretory, activities. Extract administration significantly increased PGE2 content. further experiments including in vitro metabolic stability vivo pharmacokinetics gave clear indication that (200 mg/kg) an orally safe contender agents. It can be important target studies under management system.
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