Recovery of Lymphocyte and Dendritic Cell Subsets Following Reduced Intensity Allogeneic Bone Marrow Transplantation
作者： M. Mohty , B. Gaugler , C. Faucher , D. Sainty , M. Lafage-Pochitaloff
DOI: 10.1080/10245330210000013898
关键词: Lymphocyte 、 Biology 、 CD8 、 Immunology 、 B cell 、 Marrow transplantation 、 Preparative Regimen 、 Dendritic cell 、 Toxicity 、 Immune system
摘要: AbstractApproaches using reduced conditioning regimens have been developed to obtain minimal procedure-related toxicity. Such novel therapeutic options are being explored with good preliminary results concerning feasibility and engraftment. However, many aspects remain under-evaluated few data available about immune dendritic cell (DC) reconstitution after these highly immunosuppressive regimens.We present here our in 20 patients receiving allogeneic bone marrow transplantation (allo-BMT) a preparative regimen. We evaluated the first 3 months following allo-BMT, several immunological parameters including DC subsets, compared historical obtained group of myeloablative allo-BMT patients. found an early recovery leukocytes, CD8+ NK lymphocytes. also trend towards improved B recovery. These somewhat contrast altered observed setting. In addition, we signif...
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