High bioavailability of dehydroepiandrosterone administered percutaneously in the rat.

摘要: Dehydroepiandrosterone (DHEA) administered percutaneously by twice daily application for 7 days to the dorsal skin of rat stimulates an increase in ventral prostate weight with approximately one third potency compound given subcutaneous injection. The doses required achieve a 50% reversal inhibitory effect orchiectomy are 3 and 1 mg respectively. By oral route, on other hand. DHEA has only 10-15% activity percutaneously. Taking bioavailability obtained route as 100%, it is estimated that potencies percutaneous routes 33 3% Similar ratios were when seminal vesicle used parameters androgenic activity. When examined estrogen-sensitive parameter, namely uterine ovariectomized rats, stimulatory was much less potent than its measured male animal, ovariectomy being observed at 30 weight, thus shows 10% compared route. sulfate (DHEA-S), hand, increasing after or administration. DHEA-S had 10-25% DHEA. decreased serum LH levels animals, which completely reversed treatment antiandrogen flutamide. On flutamide no significant caused DHEA, suggesting predominant estrogenic level uterus feedback control secretion. present data show relatively high and/or biological well-characterized peripheral target intracrime tissues rat.