New Amplified and Highly Expressed Genes Discovered in the ERBB2 Amplicon in Breast Cancer by cDNA Microarrays

作者: Maarit Bärlund , Outi Monni , Anne Kallioniemi , Päivikki Kauraniemi

DOI:

关键词: BiologyComparative genomic hybridizationGeneticsGene duplicationChromosomal regionMolecular biologyComplementary DNAAmpliconExpressed sequence tagDNA microarrayCopy-number variation

摘要: Amplification of the ERBB2 oncogene at 17q12 has been well documented in breast cancer and has been shown to contribute to a poor clinical outcome. However, systematic surveys of copy number and expression levels of all genes within the 17q12 region have not been performed. Here, we used cDNA and comparative genomic hybridization microarray technologies to undertake a broad survey of genes involved in the 17q12 amplification in breast cancer. A chromosomal region-specific cDNA microarray containing 217 expressed …

参考文章(30)
Hiromi Sakamoto, Masahiko Onda, Hiroki Sasaki, Masaaki Terada, Hisamaru Hirai, Nobu Akiyama, Tomoki Ishizuka, Takashi Sugimura, Yoshio Yazaki, Tatsuya Kishi, Isolation of a Candidate Gene, CAB1, for Cholesterol Transport to Mitochondria from the c-ERBB-2 Amplicon by a Modified cDNA Selection Method Cancer Research. ,vol. 57, pp. 3548- 3553 ,(1997)
B A Gusterson, R D Gelber, A Goldhirsch, K N Price, J Säve-Söderborgh, R Anbazhagan, J Styles, C M Rudenstam, R Golouh, R Reed, Prognostic importance of c-erbB-2 expression in breast cancer. International (Ludwig) Breast Cancer Study Group. Journal of Clinical Oncology. ,vol. 10, pp. 1049- 1056 ,(1992) , 10.1200/JCO.1992.10.7.1049
M van de Vijver, R van de Bersselaar, P Devilee, C Cornelisse, J Peterse, R Nusse, Amplification of the neu (c-erbB-2) oncogene in human mammmary tumors is relatively frequent and is often accompanied by amplification of the linked c-erbA oncogene. Molecular and Cellular Biology. ,vol. 7, pp. 2019- 2023 ,(1987) , 10.1128/MCB.7.5.2019
D C Allred, G M Clark, A K Tandon, R Molina, D C Tormey, C K Osborne, K W Gilchrist, E G Mansour, M Abeloff, L Eudey, HER-2/neu in node-negative breast cancer: prognostic significance of overexpression influenced by the presence of in situ carcinoma. Journal of Clinical Oncology. ,vol. 10, pp. 599- 605 ,(1992) , 10.1200/JCO.1992.10.4.599
B. Margolis, O. Silvennoinen, F. Comoglio, C. Roonprapunt, E. Skolnik, A. Ullrich, J. Schlessinger, High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains Proceedings of the National Academy of Sciences of the United States of America. ,vol. 89, pp. 8894- 8898 ,(1992) , 10.1073/PNAS.89.19.8894
W.N. Keith, F. Douglas, G.C. Wishart, H.M. McCallum, W.D. George, S.B. Kaye, R. Brown, Co-amplification of erbB2, topoisomerase II α and retinoic acid receptor α genes in breast cancer and allelic loss at topoisomerase I on chromosome 20 European Journal of Cancer. ,vol. 29, pp. 1469- 1475 ,(1993) , 10.1016/0959-8049(93)90022-8
M. Bärlund, N.N. Nupponen, R. Karhu, M.M. Tanner, P. Paavola, O.-P. Kallioniemi, A. Kallioniemi, Molecular cytogenetic mapping of 24 CEPH YACs and 24 gene-specific large insert probes to chromosome 17 Cytogenetic and Genome Research. ,vol. 82, pp. 189- 191 ,(1998) , 10.1159/000015096
S Tanaka, M Mori, T Akiyoshi, Y Tanaka, K Mafune, J R Wands, K Sugimachi, A novel variant of human Grb7 is associated with invasive esophageal carcinoma Journal of Clinical Investigation. ,vol. 102, pp. 821- 827 ,(1998) , 10.1172/JCI2921
Fabien Alpy, Marie-Elisabeth Stoeckel, Andrée Dierich, Jean-Michel Escola, Corinne Wendling, Marie-Pierre Chenard, Marie T. Vanier, Jean Gruenberg, Catherine Tomasetto, Marie-Christine Rio, The steroidogenic acute regulatory protein homolog MLN64, a late endosomal cholesterol-binding protein. Journal of Biological Chemistry. ,vol. 276, pp. 4261- 4269 ,(2001) , 10.1074/JBC.M006279200