Changes in excitatory and inhibitory synaptic potentials leading to epileptogenic activity.
作者： Philip A. Schwartzkroin , David A. Prince
DOI: 10.1016/0006-8993(80)90119-5
关键词: Bicuculline 、 Excitatory postsynaptic potential 、 Neuroscience 、 Hippocampal formation 、 Neurotransmission 、 Bursting 、 Inhibitory postsynaptic potential 、 Postsynaptic potential 、 Chemistry 、 Penicillin
摘要: The effects of the epileptogenic agent, penicillin, on excitatory and inhibitory postsynaptic potentials (EPSPs IPSPs) were studied in hippocampal vitro slice preparation. actions penicillin compared to those bicuculline, an antagonist gamma-aminobutyric acid. Neither substance enhanced monosynaptic EPSP amplitude CA1 pyramidal cells, but both bicuculline depressed IPSPs. Large depolarizations that gave rise cellular bursting activity did develop after addition or bathing medium. There was also increase incidence fast prepotentials 'd-spikes.' These observations are interpreted according hypothesis block IPSPs, consequently allow remote intrinsic events invade cell soma trigger action potentials.
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sci-hub.se 参考文章(46)
Stanley M. Crain, Neurophysiologic studies in tissue culture ,(1976)
G.F. Ayala, M. Dichter, R.J. Gumnit, H. Matsumoto, W.A. Spencer, Genesis of epileptic interictal spikes. New knowledge of cortical feedback systems suggests a neurophysiological explanation of brief paroxysms Brain Research. ,vol. 52, pp. 1- 17 ,(1973) , 10.1016/0006-8993(73)90647-1
The ionic mechanisms concerned in generating the i. p. s. ps of hippocampal pyramidal cells Proceedings of The Royal Society B: Biological Sciences. ,vol. 198, pp. 363- 384 ,(1977) , 10.1098/RSPB.1977.0103
Kin J. Futamachi, David A. Prince, Effect of penicillin on an excitatory synapse. Brain Research. ,vol. 100, pp. 589- 597 ,(1975) , 10.1016/0006-8993(75)90159-6
G. F. Ayala, S. Lin, C. Vasconetto, Penicillin as epileptogenic agent: its effect on an isolated neuron. Science. ,vol. 167, pp. 1257- 1260 ,(1970) , 10.1126/SCIENCE.167.3922.1257
Shunichi Yamagishi, Harry Grundfest, Contributions of various ions to the resting and action potentials of crayfish medial giant axons. The Journal of Membrane Biology. ,vol. 5, pp. 345- 365 ,(1971) , 10.1007/BF01957351
Philip A. Schwartzkroin, Lawrence H. Mathers, Physiological and morphological identification of a nonpyramidal hippocampal cell type Brain Research. ,vol. 157, pp. 1- 10 ,(1978) , 10.1016/0006-8993(78)90991-5
D.R. Curtis, A.W. Duggan, D. Felix, G.A.R. Johnston, Bicuculline, an antagonist of GABA and synaptic inhibition in the spinal cord of the cat. Brain Research. ,vol. 32, pp. 69- 96 ,(1971) , 10.1016/0006-8993(71)90156-9
Patrick F. Dunn, George G. Somjen, Membrane resistance, monosynaptic EPSPs, and the epileptogenic action of penicillin in spinal motoneurons Brain Research. ,vol. 128, pp. 569- 574 ,(1977) , 10.1016/0006-8993(77)90184-6
Philip A. Schwartzkroin, David A. Prince, Cellular and field potential properties of epileptogenic hippocampal slices. Brain Research. ,vol. 147, pp. 117- 130 ,(1978) , 10.1016/0006-8993(78)90776-X