Effect of physical training on lipids, lipoproteins, apolipoproteins, lipases, and endogenous sex hormones in men with premature myocardial infarction.

摘要: Abstract In 17 men, aged 27 to 54 years, with myocardial infarction 2 10 months before the current exercise study, we aimed determine whether 3 of training, at a level designed elevate high-density lipoprotein cholesterol (HDLC), would be associated changes in endogenous sex steroid hormones and postheparin hepatic lipases, hormones, lipids, lipoproteins, apolipoproteins, physical activity were interrelated. Supervised bicycle ergometry, 30 minutes, days per week, eliciting 75% maximum heart rate, produced significant training effect, 26% increase duration test standardized, submaximal workload ( P ≤ .001), reduction rate measured standardized workload, = .08. After months' mean HDLC increased 23% (30 37 mg/dL), .001, apo A2 19% (43 51 ratio total (TC) decreased .01), while estradiol (E ) levels 45% (50.1 27.8 pg/mL), .0001. 1 exercise, TC (12% [ .001], 11% .01]), low-density (LDLC) (13% .01], 12% .01]) reduced. Hepatic lipase 16% .01) .05) after exercise. There no A1, lipase, testosterone, luteinizing hormone (LH), follicle-stimulating (FSH), or weight. By stepwise regression analysis, 66% .0025) variance for from baseline day 90 was accounted independently by decrease triglyceride (F 13.2, .003), reduced on fixed load 12.7, .0035), 5.5, .036). A modest, achievable program can have cardiovascular benefit men ameliorating their hyperestrogenemia, reducing LDLC, improving ratio, elevating A2. The increment related improved capacity sustain exercise-induced reductions lipase.