Targeting the tumor microenvironment to enhance antitumor immune responses

摘要: // Kevin Van der Jeught 1 , Lukasz Bialkowski Lidia Daszkiewicz Katrijn Broos Cleo Goyvaerts Dries Renmans Sandra Lint Carlo Heirman Kris Thielemans and Karine Breckpot Laboratory of Molecular Cellular Therapy, Department Immunology-Physiology, Vrije Universiteit Brussel, Laarbeeklaan, Jette, Belgium Correspondence: Breckpot, email: Keywords : Intratumoral, Immunotherapy, Tumor microenvironment, Immunomodulation, Vaccination Received November 18, 2014 Accepted December 24, Published 26, Abstract The identification tumor-specific antigens the immune responses directed against them has instigated development therapies to enhance antitumor responses. Most these cancer immunotherapies are administered systemically rather than directly tumors. Nonetheless, numerous studies have demonstrated that intratumoral therapy is an attractive approach, both for immunization immunomodulation purposes. Injection, recruitment and/or activation antigen-presenting cells in tumor nest been extensively studied as strategies cross-prime Moreover, delivery stimulatory cytokines, blockade inhibitory cytokines checkpoint explored restore immunological fitness at site. These tumor-targeted potential induce systemic immunity without toxicity often associated with treatments. We review most promising immunotherapies, how affect such disseminated eliminated, which approaches proven successful animal models patients.