Molecular pathogenesis of multiple myeloma: basic and clinical updates
作者： Marta Chesi , P. Leif Bergsagel
DOI: 10.1007/S12185-013-1291-2
关键词: Chromosomal translocation 、 Immunoglobulin gene 、 Bortezomib 、 Hematology 、 Neuroblastoma RAS viral oncogene homolog 、 Multiple myeloma 、 KRAS 、 Ectopic expression 、 Biology 、 Genetics 、 Internal medicine
摘要: Multiple myeloma is divided into two distinct genetic subtypes based on chromosome content. Hyperdiploid characterized by multiple trisomies of chromosomes 3, 5, 7, 9 11, 15, 19 and 21, lacks recurrent immunoglobulin gene translocations. Non-hyperdiploid in contrast translocations t(4;14), t(14;16), t(14;20), t(6;14) t(11;14). A unifying event the pathogenesis dysregulated expression a cyclin D gene, either directly juxtaposition to an enhancer, as result ectopic MAF family transcription factor, or indirectly yet unidentified mechanisms. Secondary events include rearrangements MYC, activating mutations NRAS, KRAS BRAF, promiscuous array that activate NFkB deletions 17p. Among poor-risk features are del 17p gains 1q. Available evidence supports use risk-stratified approach treatment patients with myeloma, early prolonged bortezomib particularly t(4;14)
springer.com
elsevier.com
paperity.org参考文章(85)
Robert A. Kyle, Terry M. Therneau, S. Vincent Rajkumar, Dirk R. Larson, Matthew F. Plevak, Janice R. Offord, Angela Dispenzieri, Jerry A. Katzmann, L. Joseph Melton, Prevalence of Monoclonal Gammopathy of Undetermined Significance The New England Journal of Medicine. ,vol. 354, pp. 1362- 1369 ,(2006) , 10.1056/NEJMOA054494
Hervé Avet-Loiseau, Michel Attal, Philippe Moreau, Catherine Charbonnel, Frédéric Garban, Cyrille Hulin, Serge Leyvraz, Mauricette Michallet, Ibrahim Yakoub-Agha, Laurent Garderet, Gérald Marit, Lucienne Michaux, Laurent Voillat, Marc Renaud, Bernard Grosbois, Gaelle Guillerm, Lotfi Benboubker, Mathieu Monconduit, Catherine Thieblemont, Philippe Casassus, Denis Caillot, Anne-Marie Stoppa, Jean-Jacques Sotto, Marc Wetterwald, Charles Dumontet, Jean-Gabriel Fuzibet, Isabelle Azais, Véronique Dorvaux, Marc Zandecki, Régis Bataille, Stéphane Minvielle, Jean-Luc Harousseau, Thierry Facon, Claire Mathiot, Genetic abnormalities and survival in multiple myeloma: the experience of the Intergroupe Francophone du Myélome Blood. ,vol. 109, pp. 3489- 3495 ,(2007) , 10.1182/BLOOD-2006-08-040410
Suzanne Trudel, Zhi Hua Li, Ellen Wei, Marion Wiesmann, Hong Chang, Christine Chen, Donna Reece, Carla Heise, A. Keith Stewart, CHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t(4;14) multiple myeloma Blood. ,vol. 105, pp. 2941- 2948 ,(2004) , 10.1182/BLOOD-2004-10-3913
V Rouillé, I Nestorov, G Mordenti, H Goldschmidt, A Ythier, B Klein, J-F Rossi, J Moreaux, D Hose, G Requirand, M Rose, Atacicept in relapsed/refractory multiple myeloma or active Waldenström's macroglobulinemia: a phase I study British Journal of Cancer. ,vol. 101, pp. 1051- 1058 ,(2009) , 10.1038/SJ.BJC.6605241
Bart Barlogie, Mauricio Pineda-Roman, Frits van Rhee, Jeff Haessler, Elias Anaissie, Klaus Hollmig, Yazan Alsayed, Sarah Waheed, Nathan Petty, Joshua Epstein, John D. Shaughnessy, Guido Tricot, Maurizio Zangari, Jerome Zeldis, Sol Barer, John Crowley, Thalidomide arm of Total Therapy 2 improves complete remission duration and survival in myeloma patients with metaphase cytogenetic abnormalities. Blood. ,vol. 112, pp. 3115- 3121 ,(2008) , 10.1182/BLOOD-2008-03-145235
M. Attal, J.-L. Harousseau, S. Leyvraz, C. Doyen, C. Hulin, L. Benboubker, I. Y. Agha, J.-H. Bourhis, L. Garderet, B. Pegourie, C. Dumontet, M. Renaud, L. Voillat, C. Berthou, G. Marit, M. Monconduit, D. Caillot, B. Grobois, H. Avet-Loiseau, P. Moreau, T. Facon, , Maintenance therapy with thalidomide improves survival in patients with multiple myeloma Blood. ,vol. 108, pp. 3289- 3294 ,(2006) , 10.1182/BLOOD-2006-05-022962
Jesús F San Miguel, Rudolf Schlag, Nuriet K Khuageva, Meletios A Dimopoulos, Ofer Shpilberg, Martin Kropff, Ivan Spicka, Maria T Petrucci, Antonio Palumbo, Olga S Samoilova, Anna Dmoszynska, Kudrat M Abdulkadyrov, Rik Schots, Bin Jiang, Maria-Victoria Mateos, Kenneth C Anderson, Dixie L Esseltine, Kevin Liu, Andrew Cakana, Helgi Van De Velde, Paul G Richardson, None, Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma. The New England Journal of Medicine. ,vol. 359, pp. 906- 917 ,(2008) , 10.1056/NEJMOA0801479
Ana Gabrea, Maria Luisa Martelli, Ying Qi, Anna Roschke, Bart Barlogie, John D. Shaughnessy, Jeffrey R. Sawyer, W. Michael Kuehl, Secondary Genomic Rearrangements Involving Immunoglobulin or MYC Loci Show Similar Prevalences in Hyperdiploid and Nonhyperdiploid Myeloma Tumors Genes, Chromosomes and Cancer. ,vol. 47, pp. 573- 590 ,(2008) , 10.1002/GCC.20563
Michael A. Chapman, Michael S. Lawrence, Jonathan J. Keats, Kristian Cibulskis, Carrie Sougnez, Anna C. Schinzel, Christina L. Harview, Jean-Philippe Brunet, Gregory J. Ahmann, Mazhar Adli, Kenneth C. Anderson, Kristin G. Ardlie, Daniel Auclair, Angela Baker, P. Leif Bergsagel, Bradley E. Bernstein, Yotam Drier, Rafael Fonseca, Stacey B. Gabriel, Craig C. Hofmeister, Sundar Jagannath, Andrzej J. Jakubowiak, Amrita Krishnan, Joan Levy, Ted Liefeld, Sagar Lonial, Scott Mahan, Bunmi Mfuko, Stefano Monti, Louise M. Perkins, Robb Onofrio, Trevor J. Pugh, S. Vincent Rajkumar, Alex H. Ramos, David S. Siegel, Andrey Sivachenko, A. Keith Stewart, Suzanne Trudel, Ravi Vij, Douglas Voet, Wendy Winckler, Todd Zimmerman, John Carpten, Jeff Trent, William C. Hahn, Levi A. Garraway, Matthew Meyerson, Eric S. Lander, Gad Getz, Todd R. Golub, Initial genome sequencing and analysis of multiple myeloma Nature. ,vol. 471, pp. 467- 472 ,(2011) , 10.1038/NATURE09837
D. Hose, T. Reme, T. Hielscher, J. Moreaux, T. Messner, A. Seckinger, A. Benner, J. D. Shaughnessy, B. Barlogie, Y. Zhou, J. Hillengass, U. Bertsch, K. Neben, T. Mohler, J. F. Rossi, A. Jauch, B. Klein, H. Goldschmidt, Proliferation is a central independent prognostic factor and target for personalized and risk-adapted treatment in multiple myeloma. Haematologica. ,vol. 96, pp. 87- 95 ,(2011) , 10.3324/HAEMATOL.2010.030296