Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin

作者: Lyudmila V. Borovikova , Svetlana Ivanova , Minghuang Zhang , Huan Yang , Galina I. Botchkina

DOI: 10.1038/35013070

关键词: Cholinergic anti-inflammatory pathwayVagus nerveProinflammatory cytokineInflammatory reflexCytokineVagus nerve stimulationParasympathetic nervous systemEndocrinologyTumor necrosis factor alphaBiologyInternal medicine

摘要: Vertebrates achieve internal homeostasis during infection or injury by balancing the activities of proinflammatory and anti-inflammatory pathways. Endotoxin (lipopolysaccharide), …

参考文章(29)
Charles A. Dinarello, The interleukin-1 family: 10 years of discovery. The FASEB Journal. ,vol. 8, pp. 1314- 1325 ,(1994) , 10.1096/FASEBJ.8.15.8001745
R. I. Scheinman, P. C. Cogswell, A. K. Lofquist, A. S. Baldwin, Role of Transcriptional Activation of IκBα in Mediation of Immunosuppression by Glucocorticoids Science. ,vol. 270, pp. 283- 286 ,(1995) , 10.1126/SCIENCE.270.5234.283
A. A. Romanovsky, C. T. Simons, M. Szekely, V. A. Kulchitsky, The vagus nerve in the thermoregulatory response to systemic inflammation American Journal of Physiology-regulatory Integrative and Comparative Physiology. ,vol. 273, ,(1997) , 10.1152/AJPREGU.1997.273.1.R407
Marc E. Sher, Simmy Bank, Ronald Greenberg, Cristina T. Sardinha, Sam Weissman, Beverly Bailey, Robert Gilliland, Steven D. Wexner, The influence of cigarette smoking on cytokine levels in patients with inflammatory bowel disease. Inflammatory Bowel Diseases. ,vol. 5, pp. 73- 78 ,(1999) , 10.1097/00054725-199905000-00001
K. Tracey, B Beutler, S. Lowry, J Merryweather, S Wolpe, I. Milsark, R. Hariri, T. Fahey, A Zentella, J. Albert, al. et, Shock and tissue injury induced by recombinant human cachectin. Science. ,vol. 234, pp. 470- 474 ,(1986) , 10.1126/SCIENCE.3764421
William J. Sandborn, Transdermal Nicotine for Mildly to Moderately Active Ulcerative Colitis Annals of Internal Medicine. ,vol. 126, pp. 364- 371 ,(1997) , 10.7326/0003-4819-126-5-199703010-00004
James M. Lipton, Anna Catania, Anti-inflammatory actions of the neuroimmunomodulator α-MSH Immunology Today. ,vol. 18, pp. 140- 145 ,(1997) , 10.1016/S0167-5699(97)01009-8
M Fleshner, L.E Goehler, B.A Schwartz, M McGorry, D Martin, S.F Maier, L.R Watkins, Thermogenic and corticosterone responses to intravenous cytokines (IL-1β and TNF-α) are attenuated by subdiaphragmatic vagotomy Journal of Neuroimmunology. ,vol. 86, pp. 134- 141 ,(1998) , 10.1016/S0165-5728(98)00026-5
Christian Woiciechowsky, Khusru Asadullah, Dirk Nestler, Beatrice Eberhardt, Cornelia Platzer, Britta Schöning, Frauke Glöckner, Wolfgang R. Lanksch, Hans-Dieter Volk, Wolf-Diatrich Döcke, Sympathetic activation triggers systemic interleukin-10 release in immunodepression induced by brain injury. Nature Medicine. ,vol. 4, pp. 808- 813 ,(1998) , 10.1038/NM0798-808
G.S. Madretsma, G.J. Donze, A.P.M. van Dijk, C.J.A.M. Tak, J.H.P. Wilson, F.J. Zijlstra, Nicotine inhibits the in vitro production of interleukin 2 and tumour necrosis factor-α by human mononuclear cells Immunopharmacology. ,vol. 35, pp. 47- 51 ,(1996) , 10.1016/0162-3109(96)00122-1