Complications of preinjury warfarin use in the trauma patient.

作者: Alfred A. Mina , Holly A. Bair , Greg A. Howells , Phillip J. Bendick

DOI: 10.1097/01.TA.0000063271.05829.15

关键词: ChemoprophylaxisProspective cohort studyAnticoagulantInjury Severity ScoreAnesthesiaHead injuryHead traumaSurgeryWarfarinMortality rateMedicine

摘要: Background: The frequency of use warfarin anticoagulation increases significantly in the elderly population. It remains controversial whether this puts these patients at increased risk for hemorrhagic complications after trauma. Methods: We prospectively evaluated consecutive trauma who were taking and compared their outcomes to a group age-matched with head injuries but not warfarin. Results: One hundred fifty-nine on evaluated, 94 (59%) some type trauma; 25 (27%) had documented intracranial Fifteen died (9.4%); they an international normalized ratio 3.3 ± 1.6 versus 3.0 2.1 survivors (p = 0.585). Twelve deaths (48%). Three without injury (5%) other causes related or hemorrhage mean 13 days admission. Ten 12 loss consciousness (LOC); two secondary isolated no LOC. Of 70 warfarin, 47 (67%) 5 (10%) < 0.001 both values study patients). There significant differences comparing those terms age, gender, mechanism injury, Injury Severity Score, Glasgow Come Scale score. Conclusion: conclude that preinjury does place patient fatal absence Furthermore, presence alone is predictive mortality. However, strongly associated mortality rate higher than are LOC also mortality, reliably indicate death.

参考文章(8)
Elaine M. Hylek, Risk Factors for Intracranial Hemorrhage in Outpatients Taking Warfarin Annals of Internal Medicine. ,vol. 120, pp. 897- 902 ,(1994) , 10.7326/0003-4819-120-11-199406010-00001
Dawn M. Kennedy, Mark D. Cipolle, Michael D. Pasquale, Thomas Wasser, Impact of preinjury warfarin use in elderly trauma patients Journal of Trauma-injury Infection and Critical Care. ,vol. 48, pp. 451- 453 ,(2000) , 10.1097/00005373-200003000-00012
Lawrence Lottenberg, Robert Holtzman, Vicki J. Bennett-Shipman, Greg Zorman, Luis Rodriguez, Amir Karni, Lee Carter, Thomas Bass, Traumatic head injury in the anticoagulated elderly patient: a lethal combination. American Surgeon. ,vol. 67, pp. 1098- 1100 ,(2001)
Randolph Wojcik, Mark D. Cipolle, Elizabeth Seislove, Thomas E. Wasser, Michael D. Pasquale, Preinjury warfarin does not impact outcome in trauma patients. Journal of Trauma-injury Infection and Critical Care. ,vol. 51, pp. 1147- 1152 ,(2001) , 10.1097/00005373-200112000-00021
Peter C Ferrera, Joel M Bartfield, Outcomes of anticoagulated trauma patients. American Journal of Emergency Medicine. ,vol. 17, pp. 154- 156 ,(1999) , 10.1016/S0735-6757(99)90050-5
A. R. Wintzen, J. G. P. Tijssen, Subdural Hematoma and Oral Anticoagulant Therapy JAMA Neurology. ,vol. 39, pp. 69- 72 ,(1982) , 10.1001/ARCHNEUR.1982.00510140003001
Gregory Garra, Ashraf H. Nashed, Leo Capobianco, Minor Head Trauma in Anticoagulated Patients Academic Emergency Medicine. ,vol. 6, pp. 121- 124 ,(1999) , 10.1111/J.1553-2712.1999.TB01048.X
Alfred A. Mina, John F. Knipfer, David Y. Park, Holly A. Bair, Greg A. Howells, Phillip J. Bendick, Intracranial Complications of Preinjury Anticoagulation in Trauma Patients with Head Injury Journal of Trauma-injury Infection and Critical Care. ,vol. 53, pp. 668- 672 ,(2002) , 10.1097/00005373-200210000-00008