Association between the COMT locus and obsessive-compulsive disorder in females but not males.
作者： John P. Alsobrook , Ada H. Zohar , Marion Leboyer , Nadia Chabane , Richard P. Ebstein
DOI: 10.1002/AJMG.10040
关键词: Allele 、 Proband 、 Locus (genetics) 、 Anxiety disorder 、 Genotype frequency 、 Allele frequency 、 Haplotype 、 Genotype 、 Biology 、 Genetics
摘要: A polymorphism in the coding region of catechol-O-methyltransferase gene (COMT) was previously reported to be associated with obsessive-compulsive disorder (OCD), particularly male probands. We attempted replicate previous finding using a family-based genetic design haplotype relative risk (HRR) and transmission disequilibrium (TDT) analyses. Fifty-six OCD probands their parents were genotyped for COMT locus established methods. Analysis allele genotype frequencies between proband genotypes control (parental nontransmitted) failed gender divergence, gave no evidence overall association, nor linkage detected by TDT. However, further analysis mildly significant association low-activity female (P = 0.049), but not These findings indicate that may etiologically relevant gender-specific manner opposite shown studies. © 2001 Wiley-Liss, Inc.
sci-hub.se 参考文章(37)
Maria Karayiorgou, Christina Sobin, Maude L. Blundell, Brandi L. Galke, Lubomira Malinova, Pablo Goldberg, Jurg Ott, Joseph A. Gogos, Family-based association studies support a sexually dimorphic effect of COMT and MAOA on genetic susceptibility to obsessive-compulsive disorder Biological Psychiatry. ,vol. 45, pp. 1178- 1189 ,(1999) , 10.1016/S0006-3223(98)00319-9
Svenn Torgersen, Genetic Factors in Anxiety Disorders Archives of General Psychiatry. ,vol. 40, pp. 1085- 1089 ,(1983) , 10.1001/ARCHPSYC.1983.01790090047007
Gavin Andrews, Gavin Stewart, Rae Allen, A.S. Henderson, The genetics of six neurotic disorders: a twin study. Journal of Affective Disorders. ,vol. 19, pp. 23- 29 ,(1990) , 10.1016/0165-0327(90)90005-S
Meg A Palmatier, A.Min Kang, Kenneth K Kidd, Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles Biological Psychiatry. ,vol. 46, pp. 557- 567 ,(1999) , 10.1016/S0006-3223(99)00098-0
Joseph D. Terwilliger, Jurg Ott, A haplotype-based 'haplotype relative risk' approach to detecting allelic associations. Human Heredity. ,vol. 42, pp. 337- 346 ,(1992) , 10.1159/000154096
Debomoy K. Lahiri, John I. Numberger, A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies Nucleic Acids Research. ,vol. 19, pp. 5444- 5444 ,(1991) , 10.1093/NAR/19.19.5444
William B. Parker, Yung Chi Cheng, Metabolism and mechanism of action of 5-fluorouracil Pharmacology & Therapeutics. ,vol. 48, pp. 381- 395 ,(1990) , 10.1016/0163-7258(90)90056-8
J D Flory, S B Manuck, R E Ferrell, K M Dent, D G Peters, M F Muldoon, Neuroticism is not associated with the serotonin transporter (5-HTTLPR) polymorphism. Molecular Psychiatry. ,vol. 4, pp. 93- 96 ,(1999) , 10.1038/SJ.MP.4000466
Maria Cristina Cavallini, Lorenza Pasquale, Laura Bellodi, Enrico Smeraldi, Complex segregation analysis for obsessive compulsive disorder and related disorders. American Journal of Medical Genetics. ,vol. 88, pp. 38- 43 ,(1999) , 10.1002/(SICI)1096-8628(19990205)88:1<38::AID-AJMG7>3.0.CO;2-#
Laura Bellodi, Gabriella Sciuto, Giuseppina Diaferia, Paolo Ronchi, Enrico Smeraldi, Psychiatric disorders in the families of patients with obsessive-compulsive disorder Psychiatry Research. ,vol. 42, pp. 111- 120 ,(1992) , 10.1016/0165-1781(92)90075-E