Effects of Delayed Wound Excision and Grafting in Severely Burned Children

作者: Wu Xiao-Wu

DOI: 10.1001/ARCHSURG.137.9.1049

关键词: MedicineDebridementIncidence (epidemiology)TransplantationSepsisWound healingSurgeryBlood transfusionTotal body surface areaComplication

摘要: Hypothesis Advances in burn treatment including early excision of the wound have increased survival patients treated at specialized centers. We hypothesized that with delayed and grafting would experience deleterious outcomes. Methods From 1995 to 1999, 157 children acute burns covering 40% or more total body surface area having than 10% full-thickness were admitted our institution within 2 weeks injury. Among them, 86, 42, 29 underwent first operation on days 0 2, 3 6, 7 14 after burn, respectively. Outcomes observed mortality, number operative procedures, length hospitalization, blood transfused, incidence bacterial fungal contamination, invasive infection, sepsis. Results Demographic data for groups showed no differences sex burned. Mortality procedures transfusions not different between groups. Hospitalizations longer groups, which was associated a higher significant contamination ( P = .008). Invasive infection also significantly delay .04). Conclusions Delays hospitalization closure, as well rates Our indicate 48 hours is optimal pediatric massive burns.

参考文章(25)
Charles R. Baxter, Management of burn wounds. Dermatologic Clinics. ,vol. 11, pp. 709- 714 ,(1993) , 10.1016/S0733-8635(18)30223-7
RONALD G. TOMPKINS, JOHN F. BURKE, DAVID A. SCHOENFELD, CONRADO C. BONDOC, GLENN C. BEHRINGER, FREDERICK W. ACKROYD, WILLIAM C. QUINBY, Prompt eschar excision: a treatment system contributing to reduced burn mortality. A statistical evaluation of burn care at the Massachusetts General Hospital (1974-1984). Annals of Surgery. ,vol. 204, pp. 272- 282 ,(1986) , 10.1097/00000658-198609000-00006
Hiromasa Yamamoto, Soranit Siltharm, Suzan deSerres, C.Scott Hultman, Anthony A. Meyer, Immediate burn wound excision restores antibody synthesis to bacterial antigen. Journal of Surgical Research. ,vol. 63, pp. 157- 162 ,(1996) , 10.1006/JSRE.1996.0240
O. Cetinkale, K. M. Ulualp, F. Ayan, M. Düren, O. Cizmeci, A. Pusane, Early wound excision and skin grafting restores cellular immunity after severe burn trauma. British Journal of Surgery. ,vol. 80, pp. 1296- 1298 ,(2005) , 10.1002/BJS.1800801025
John B. Pietsch, David T. Netscher, Hirikati S. Nagaraj, Diller B. Groff, Early excision of major burns in children: Effect on morbidity and mortality Journal of Pediatric Surgery. ,vol. 20, pp. 754- 757 ,(1985) , 10.1016/S0022-3468(85)80039-7
Jun-Zheng Wu, Cora K. Ogle, Jun-Xian Mao, Kathy Szczur, Josef E. Fischer, James D. Ogle, The increased potential for the production of inflammatory cytokines by Kupffer cells and splenic macrophages eight days after thermal injury Inflammation. ,vol. 19, pp. 529- 541 ,(1995) , 10.1007/BF01539133
David W. Hart, Steven E. Wolf, David L. Chinkes, Dennis C. Gore, Ronald P. Mlcak, Robert B. Beauford, Michael K. Obeng, Sophia Lal, Warren F. Gold, Robert R. Wolfe, David N. Herndon, Determinants of skeletal muscle catabolism after severe burn. Annals of Surgery. ,vol. 232, pp. 455- 465 ,(2000) , 10.1097/00000658-200010000-00001
MANU H. DESAI, DAVID N. HERNDON, LYLE BROEMELING, ROBERT E. BARROW, RAY J. NICHOLS, RANDI L. RUTAN, Early burn wound excision significantly reduces blood loss. Annals of Surgery. ,vol. 211, pp. 753- 762 ,(1990) , 10.1097/00000658-199006000-00015
C. Scott Hultman, Hiromasa Yamamoto, Suzan deSerres, Jeffrey A. Frelinger, Anthony A. Meyer, Early but not late burn wound excision partially restores viral-specific T lymphocyte cytotoxicity Journal of Trauma-injury Infection and Critical Care. ,vol. 43, pp. 441- 447 ,(1997) , 10.1097/00005373-199709000-00009
DAVID N. HERNDON, DONALD H. PARKS, Comparison of Serial Debridement and Autografting and Early Massive Excision with Cadaver Skin Overlay in the Treatment of Large Burns in Children Journal of Trauma-injury Infection and Critical Care. ,vol. 26, pp. 149- 152 ,(1986) , 10.1097/00005373-198602000-00009