Inhibited breathing decreases renal sodium excretion.

作者: D. E. Anderson , A. Y. Bagrov , J. L. Austin

DOI: 10.1097/00006842-199507000-00009

关键词: BreathingTidal volumeDiuresisSodiumInternal medicineHeart rateBlood pressureEndocrinologyNatriuresisRenal sodium excretionMedicine

摘要: This study tested the hypothesis that breathing at upper end of normal range tidal CO2 decreases renal sodium excretion. Normotensive human subjects learned to self-regulate using a respiratory gas monitor and feedback procedure. Urine flow rates were increased by standardized water drinking regimen. Urinary volume potassium excretion decreased during 30 minutes inhibited (i.e. high CO2) breathing, compared with levels preceding after task performance. Blood pressure, but not heart rate, Plasma increase under these conditions is indicated observation urinary an endogenous digoxin-like factor was increased. The physiological mechanism which elicits retention remains be determined. pattern could mediate role behavioral stress in some forms hypertension.

参考文章(22)
V. K. Somers, A. L. Mark, D. C. Zavala, F. M. Abboud, Contrasting effects of hypoxia and hypercapnia on ventilation and sympathetic activity in humans Journal of Applied Physiology. ,vol. 67, pp. 2101- 2106 ,(1989) , 10.1152/JAPPL.1989.67.5.2101
V Novak, P Novak, J de Champlain, R Nadeau, Altered cardiorespiratory transfer in hypertension. Hypertension. ,vol. 23, pp. 104- 113 ,(1994) , 10.1161/01.HYP.23.1.104
Christopher J. Lynch, Michael L. Steer, Janet L. Smart, Richard C. Deth, Differences in the Role of Na+/K+-ATPase during α1-Adrenergic Events in Rat and Rabbit Aorta Pharmacology. ,vol. 33, pp. 221- 234 ,(1986) , 10.1159/000138220
Shabtai Varsano, Lotan Shilo, Israel Bruderman, Sarah Dolev, Louis Shenkman, Endogenous Digoxin-like Immunoreactive Factor Is Elevated in Advanced Chronic Respiratory Failure Chest. ,vol. 101, pp. 146- 149 ,(1992) , 10.1378/CHEST.101.1.146
K. Light, J. Koepke, P. Obrist, P. Willis, Psychological stress induces sodium and fluid retention in men at high risk for hypertension. Science. ,vol. 220, pp. 429- 431 ,(1983) , 10.1126/SCIENCE.6836285
Alexei Y. Bagrov, Natalia I. Roukoyatkina, Olga V. Federova, Alexander G. Pinaev, Maria V. Ukhanova, Digitalis-like and vasoconstrictor effects of endogenous digoxin-like factor(s) from the venom of Bufo marinus toad European Journal of Pharmacology. ,vol. 234, pp. 165- 172 ,(1993) , 10.1016/0014-2999(93)90950-M
C Hinojosa-Laborde, R L Thunhorst, A W Cowley, Vasoconstriction during volume expansion is independent of central control. Hypertension. ,vol. 15, pp. 712- 717 ,(1990) , 10.1161/01.HYP.15.6.712
R. G. Morris, D. B. Frewin, N. C. Saccoia, W. L. Goldsworthy, W. S. Jeffries, A. J. McPhee, Interference from digoxin-like immunoreactive substance(s) in commercial digoxin kit assay methods. European Journal of Clinical Pharmacology. ,vol. 39, pp. 359- 363 ,(1990) , 10.1007/BF00315410
Jennifer A. Haythornthwaite, David E. Anderson, Lisa H. Moore, Social and behavioral factors associated with episodes of inhibitory breathing Journal of Behavioral Medicine. ,vol. 15, pp. 573- 588 ,(1992) , 10.1007/BF00844857