Cytogenetic Profile of Minimally Differentiated (fab M0) Acute Myeloid-leukemia - Correlation With Clinicobiologic Findings

摘要: Cytogenetic data were studied in 26 patients with de novo acute myeloid leukemia (AML) minimal differentiation, corresponding to the M0 subtype of French-American-British classification, correlation cytoimmunologic and clinical findings. Clonal abnormalities detected 21 cases (80.7%), 12 which had a complex karyotype. Partial or total monosomy 5q and/or 7q was found, either as sole aberration all abnormal metaphases, 11 patients; 8 cases, additional chromosome changes present, including rearrangements involving 12p12-13 2p12-15 seen 3 each. Five trisomy 13 possible primary change; 5 nonrecurrent chromsome observed. Comparison these findings from 42 AML-M1 shows that karyotypes, unbalanced (-5/5q- -7/7q- +13) observed much more frequently AML-M0 than AML-M1. Patients 7 showed trilineage myelodysplasia low white blood cell count. Despite their relatively young age, complete remission achieved 4 only. +13 elderly males frequent professional exposure myelotoxic agents. Unlike clonal abnormalities, most normal karyotype 1% 2% peroxidase-positive blast cells at light microscopy CR. It is concluded (1) distinct cytogenetic profile, partially recalling therapy-related AML, (2) different groups can be idenitified showing characteristic clinicobiologic features, (3) may account for unfavorable outcome patients. (C) 1995 by The American Society Hematology.