Changes in dihydrotestosterone metabolism and the development of benign prostatic hyperplasia in the aging beagle

摘要: Abstract Previous studies have demonstrated that the 2–3-fold abnormal elevation in prostatic dihydrotestosterone (DHT) content characteristically associated with canine benign hyperplasia (BPH) is due to a shift overall balance complex metabolism of DHT gland itself [1,2]. Since incidence BPH increases host age [3], question arises as whether characteristic general process aging or specific development BPH. To resolve this issue, activities androgen were quantitatively assayed tissue from large series age-matched normal and dogs ranging 0.7–9.0 years. These analyses revealed that, regardless host, there consistent statistical increase several which produce (i.e. 5α-reductase, 3α-HSOR oxidase, 17β-HSOR reductase) without concomitant any remove steroid compared tissue. results suggest changes tissue's ability for net formation are specifically not simply per se.